What do systematic reviews say?

Umeclidinium bromide vs placebo

Umeclidinium bromide showed no clear difference in non‐fatal serious adverse events compared with placebo (moderate certainty).

• Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD) 2017 · Cochrane Headline outcomes only
  OR 1.33 [0.89, 2]
  4 studies · 1922 participants
  Moderate

Umeclidinium bromide vs placebo

Umeclidinium bromide showed no clear difference in number of participants with hospital admissions due to COPD… compared with placebo (low certainty).

• Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD) 2017 · Cochrane Headline outcomes only
  OR 0.86 [0.25, 2.92]
  4 studies · 1922 participants
  Low

Umeclidinium bromide vs placebo

Umeclidinium bromide leads to higher number of participants with ≥ 1 unit improvement in TDI focal score compared with placebo (high certainty).

• Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD) 2017 · Cochrane Headline outcomes only
  OR 1.71 [1.37, 2.15]
  3 studies · 1441 participants
  High

Umeclidinium bromide vs placebo

• Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD) 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 1381 participants
  High

Umeclidinium bromide vs placebo

Umeclidinium bromide showed no clear difference in adverse events (not including serious adverse events) compared with placebo (moderate certainty).

• Umeclidinium bromide versus placebo for people with chronic obstructive pulmonary disease (COPD) 2017 · Cochrane Headline outcomes only
  OR 1.06 [0.85, 1.31]
  4 studies · 1922 participants
  Moderate

AeriSeal vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Low

Airway bypass stents vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 350 participants
  High

Airway bypass stents vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 350 participants
  High

Airway bypass stents vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 350 participants
  Moderate

Airway bypass stents vs control

Airway bypass stents showed no clear difference in adverse events at end of compared with control (moderate certainty).

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  OR 1.33 [0.65, 2.73]
  1 study · 315 participants
  Moderate

Airway bypass stents vs control

The review found no eligible studies for this question.

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Endobronchial coils vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 146 participants
  Moderate

Endobronchial coils vs control

Endobronchial coils showed no clear difference in mortality at end of compared with control (moderate certainty).

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  OR 1.49 [0.67, 3.29]
  3 studies · 461 participants
  Moderate

Endobronchial coils vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 461 participants
  Moderate

Endobronchial coils vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 461 participants
  High

Endobronchial coils vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 461 participants
  Low

AeriSeal vs control

AeriSeal showed no clear difference in mortality at end of compared with control (low certainty).

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  OR 2.9 [0.14, 62.15]
  1 study · 95 participants
  Low

Endobronchial coils vs control

Endobronchial coils leads to higher adverse events at end of compared with control (high certainty).

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  OR 2.14 [1.41, 3.23]
  3 studies · 461 participants
  High

Endobronchial coils vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Moderate

Endobronchial valves vs control

• Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease 2017 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 703 participants
  Low