Findings

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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Clobetasol propionate 0.025% microspheres vs Clobetasol propionate 0.025% ointment

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Clobetasol propionate 0.025% microspheres showed no clear difference in clinical resolution compared with clobetasol propionate 0.025% ointment; GRADE not reported.

1 finding from 1 review

Levofloxacin + SRP vs SRP

Probing pocket depth · Adults with chronic periodontitis

Levofloxacin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

2 findings from 1 review

Resin-based fissure sealant plus fluoride varnish vs Fluoride varnish

Number of visits to the dentist for repair of sealant or fluoride varnish application · Children and adolescents (general population, aged under 20 years)

The review found no eligible studies for this question.

1 finding from 1 review

Counter-stimulation and distraction (combined) vs Conventional treatment

Adverse effects · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Clinical examination with 24-month recall vs Clinical examination with 6-month recall

Oral health attitudes (1-7 scale) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with 24-month recall showed no clear difference in oral health attitudes (1-7 scale) compared with clinical examination with 6-month recall; GRADE not reported.

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Adverse events · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.

1 finding from 1 review

Electrical counter-stimulation device (DentalVibe) vs Conventional treatment (no stimulation)

Successful LA/painless treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Clinical examination with 24-month recall vs Clinical examination with 6-month recall

Dental caries · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with 24-month recall showed no clear difference in dental caries: number of tooth surfaces with any caries (ICDAS 1-6) compared with clinical examination with 6-month recall (moderate certainty).

1 finding from 1 review

High-volume evacuation (HVE) vs Conventional dental suction (low-volume evacuator / saliva ejector)

Reduction in level of contamination in aerosols (CFU) during ultrasonic scaling at 40 cm from mouth · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether high-volume evacuation (HVE) changes reduction in level of contamination in aerosols (CFU) during… compared with conventional dental suction (low-volume evacuator / saliva ejector) (very low certainty).

1 finding from 1 review

Clinical examination with 24-month recall vs Clinical examination with 6-month recall

Cost (patient perspective): total cost per patient (GBP) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with 24-month recall led to lower cost (patient perspective): total cost per patient (GBP) compared with clinical examination with 6-month recall; GRADE not reported.

1 finding from 1 review

Hypnosis vs Conventional treatment

Intraoperative pain · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

It is very uncertain whether hypnosis changes self- or observational assessment of intraoperative… compared with conventional treatment (very low certainty).

1 finding from 1 review

All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic odds ratio (DOR) by subgroup: Permanent/mixed dentition (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Amoxicillin + metronidazole + SRP vs SRP

Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)

Amoxicillin + metronidazole + SRP led to lower percentage of closed pockets compared with SRP; GRADE not reported.

3 findings from 1 review

Dexamethasone mouthwash plus nystatin vs Photodynamic therapy

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review