Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in total mortality compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review

Altered fractionation radiotherapy plus chemotherapy vs Chemoradiotherapy with standard (conventional) fractionation

Outcome not reported · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

The review found no eligible studies for this question.

1 finding from 1 review

Accelerated radiotherapy (no split, boost or hyperfractionation) vs Conventional (standard) fractionation radiotherapy

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
1 finding from 1 review

Hyperfractionated/accelerated split-course radiotherapy vs Accelerated radiotherapy with concomitant boost

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
1 finding from 1 review

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Overall symptoms, pain and headache (relief from symptoms assessed by global measures) · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Pre-operative radiotherapy (plus surgery) vs surgery

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative radiotherapy (plus surgery) showed no clear difference in locoregional control compared with surgery alone; GRADE not reported.

1 finding from 1 review

Altered fractionation radiotherapy vs Chemoradiotherapy (concurrent, standard fractionation)

Outcome not reported · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

The review found no eligible studies for this question.

1 finding from 1 review

Potassium containing toothpaste (5% potassium nitrate) vs Control toothpaste (without potassium)

Tactile sensitivity (method a, ordinal scale) · Healthy human adults (18 years or more) with dentine hypersensitivity from exposed root surfaces

Potassium containing toothpaste (5% potassium nitrate) led to lower tactile sensitivity (method a, ordinal scale) compared with control toothpaste (without potassium); GRADE not reported.

1 finding from 1 review

Potassium containing toothpaste (5% potassium nitrate) vs Control toothpaste (without potassium)

Thermal sensitivity · Healthy human adults (18 years or more) with dentine hypersensitivity from exposed root surfaces

Potassium containing toothpaste (5% potassium nitrate) led to lower thermal sensitivity compared with control toothpaste (without potassium); GRADE not reported.

1 finding from 1 review

Potassium containing toothpaste (5% potassium nitrate) vs Control toothpaste (without potassium)

Subjective assessment of sensitivity · Healthy human adults (18 years or more) with dentine hypersensitivity from exposed root surfaces

Potassium containing toothpaste (5% potassium nitrate) showed no clear difference in subjective assessment of sensitivity compared with control toothpaste (without potassium); GRADE not reported.

1 finding from 1 review

Potassium containing toothpaste (5% potassium nitrate) vs Control toothpaste (without potassium)

Air blast sensitivity · Healthy human adults (18 years or more) with dentine hypersensitivity from exposed root surfaces

Potassium containing toothpaste (5% potassium nitrate) led to lower air blast sensitivity compared with control toothpaste (without potassium); GRADE not reported.

1 finding from 1 review

Potassium containing toothpaste (5% potassium nitrate) vs Control toothpaste (without potassium)

Tactile sensitivity (method b, continuous probe) · Healthy human adults (18 years or more) with dentine hypersensitivity from exposed root surfaces

Potassium containing toothpaste (5% potassium nitrate) led to higher tactile sensitivity (method b, continuous probe) compared with control toothpaste (without potassium); GRADE not reported.

1 finding from 1 review