Findings

What do systematic reviews say?

1,247 questions · 1,321 findings · 334 reviews

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No studies found 73 · 5.5%GRADE not reported 31 · 2.3%Very low 500 · 37.9%Low 406 · 30.7%Moderate 247 · 18.7%High 64 · 4.8%

ICS + LAMA add‐on vs ICS dose increase

Mean exacerbations requiring a course of oral corticosteroids · adults with asthma

ICS + LAMA add‐on showed no clear difference in exacerbations requiring a course of OCSa 14 weeks compared with ICS dose increase (low certainty).

1 finding from 1 review

Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults… 2015 · Cochrane Headline outcomes only
OR 0.57 [0.22, 1.43]
1 study · 174 participants
Low

ICS + LAMA add‐on vs ICS dose increase

AQLQ score (Scale 1 to 7, where 1 = severely impaired and 7 = no impairment) · adults with asthma

1 finding from 1 review

Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Low

ICS + LAMA add‐on vs ICS dose increase

SAEs · adults with asthma

ICS + LAMA add‐on showed no clear difference in SAEs (all cause) compared with ICS dose increase (low certainty).

1 finding from 1 review

Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults… 2015 · Cochrane Headline outcomes only
OR 1 [0.2, 5.09]
1 study · 174 participants
Low

ICS + LAMA add‐on vs ICS dose increase

Exacerbations needing hospitalisation · adults with asthma

ICS + LAMA add‐on showed no clear difference in exacerbations requiring hospitalisation 14 weeks compared with ICS dose increase (low certainty).

1 finding from 1 review

Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults… 2015 · Cochrane Headline outcomes only
OR 1 [0.06, 16.24]
1 study · 174 participants
Low

ICS + LAMA add‐on vs ICS dose increase

Exacerbations leading to ED visits · adults with asthma

ICS + LAMA add‐on showed no clear difference in exacerbations requiring ED visit 14 weeks compared with ICS dose increase (low certainty).

1 finding from 1 review

Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults… 2015 · Cochrane Headline outcomes only
OR 0.49 [0.09, 2.77]
1 study · 174 participants
Low

ICS + LAMA add‐on vs ICS dose increase

FEV1 · adults with asthma

1 finding from 1 review

Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Moderate

ICS + LAMA add‐on vs ICS dose increase

ACQ score Scale = 0 to 6 (0 = no impairment; 6 = maximum impairment) · adults with asthma

1 finding from 1 review

Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Low