Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Steroid plus vitamin D vs vitamin D

Number of participants withdrawing due to adverse events (AE) · scalp psoriasis

Steroid plus vitamin D leads to lower number of participants withdrawing due to adverse events compared with vitamin D (high certainty).

1 finding from 1 review

Steroid plus vitamin D vs vitamin D

Number of participants achieving 'response' by PGA · scalp psoriasis

Steroid plus vitamin D probably leads to higher number of participants achieving 'response' by PGA compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'response' by IGA · scalp psoriasis

Steroid leads to higher number of participants achieving 'response' by IGA compared with vitamin D (high certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants withdrawing due to adverse events (AE) · scalp psoriasis

Steroid probably leads to lower number of participants withdrawing due to adverse events (AE) compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroids vs vitamin D

Number of participants achieving 'response' by PGA · scalp psoriasis

Steroid probably leads to higher number of participants achieving 'response' by PGA compared with vitamin D (moderate certainty).

1 finding from 1 review

Steroid plus vitamin D vs steroids

Number of participants achieving 'clearance' by IGA · scalp psoriasis

Steroid plus vitamin D probably leads to higher number of participants achieving 'clearance' by IGA compared with steroid (moderate certainty).

1 finding from 1 review

Steroid plus vitamin D vs steroids

Number of participants achieving 'response' by IGA · scalp psoriasis

Steroid plus vitamin D probably leads to higher number of participants achieving 'response' by IGA compared with steroid (moderate certainty).

1 finding from 1 review

Steroid plus vitamin D vs steroids

Number of participants withdrawing due to adverse events (AE) · scalp psoriasis

Steroid plus vitamin D showed no clear difference in number of participants withdrawing due to adverse events (AE) compared with steroid (moderate certainty).

1 finding from 1 review

Daily application of sunscreen vs discretionary use

Cutaneous squamous cell carcinoma Confirmed clinically or by histopathology · general participants

Daily application of sunscreen showed no clear difference in cutaneous squamous cell carcinoma Confirmed clinically or by… compared with discretionary use (low certainty).

1 finding from 1 review

Fractional laser vs radiofrequency

Participant‐assessed adverse events (short‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Fractional laser vs combined chemical peeling plus needling

Participant‐reported scar improvement (long‐term) · people with acne scars

It is very uncertain whether fractional laser changes participant‐reported scar improvement (long‐term) N of participants… compared with combined chemical peeling plus needling (very low certainty).

1 finding from 1 review