Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Endothelin receptor antagonists vs placebo

Proportion of participants with improved functional class mean duration of study 16.8 weeks · pulmonary arterial hypertension

Endothelin receptor antagonists probably leads to higher proportion of participants with improved functional class mean… compared with placebo (moderate certainty).

1 finding from 1 review

Integrated disease management interventions vs usual care

Respiratory‐related hospital admissions · patients with chronic obstructive pulmonary disease

Integrated disease management interventions leads to lower respiratory‐related hospital admissions compared with usual care (high certainty).

1 finding from 1 review