Cochrane · systematic review · CD009593
Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis
Zifodya, JS, Kreniske, JS, Schiller, I, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
8
No studies
2
Included studies
NR
No studies 2 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 8 · 80%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsXpert Ultra versus Xpert MTB/RIF for the detection of pulmonary tuberculosis*
Population: adults with presumptive pulmonary tuberculosis. Participants were unselected, meaning they were not enrolled in a study based on microscopy smear results or history of tuberculosis Role: an initial test Index tests: Xpert Ultra and Xpert MTB/RIF Threshold for index tests: an automated result is provided Reference standards: solid or liquid culture Studies: cross‐sectional and cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Test result Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | NR | No studies |
True positives (TP) Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | 7 studies · 983 participants | High |
False negatives (FN) Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | 7 studies · 983 participants | High |
True negatives (TN) Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | 7 studies · 1852 participants | High |
False positives (FP) Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | 7 studies · 1852 participants | High |
Xpert Ultra versus Xpert MTB/RIF for the detection of rifampicin resistance*
Population: adults with presumptive pulmonary tuberculosis Role: an initial test Index tests: Xpert Ultra and Xpert MTB/RIF Threshold for index tests: an automated result is provided Reference standards: drug susceptibility testing, line probe assay Studies: cross‐sectional and cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Test result Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | NR | No studies |
True positives (TP) Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | 5 studies · 238 participants | High |
False negatives (FN) Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | 5 studies · 238 participants | High |
True negatives (TN) Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | 5 studies · 692 participants | High |
False positive (FP) Xpert Ultra vs Xpert MTB/RIF | no estimate extracted | 5 studies · 692 participants | High |