What do systematic reviews say?

Mepolizumab 300 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 451 participants
  Moderate

Benralizumab 10 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 680 participants
  Moderate

Benralizumab 30 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1333 participants
  Moderate

Benralizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1433 participants
  High

Benralizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1351 participants
  High

Mepolizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 911 participants
  Moderate

Mepolizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1285 participants
  Moderate

Myofunctional therapy plus nasal washing vs Nasal washing alone

Myofunctional therapy plus nasal washing showed no clear difference in AHI score reduction to below 5 points. compared with nasal washing alone (low certainty).

• Myofunctional therapy (oropharyngeal exercises) for obstructive sleep apnoea 2020 · Cochrane Headline outcomes only
  OR 12.5 [0.84, 186.3]
  1 study · 13 participants
  Low

Digital targeted client communication via mobile devices vs non‐digital targeted client communication (parents of children aged under five years)

Digital targeted client communication via mobile devices showed no clear difference in health behaviour change – hygiene practices (oral health in children… compared with non‐digital targeted client communication (parents of children aged… (low certainty).

• Targeted client communication via mobile devices for improving maternal, neonatal, and child health 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 143 participants
  Low

Digital targeted client communication via mobile devices vs standard skin care or no skin care intervention

Digital targeted client communication via mobile devices showed no clear difference in health status and well‐being ‐ Repeat abortion following an earlier… compared with standard care or no intervention (low certainty).

• Targeted client communication via mobile devices for improving sexual and reproductive health 2020 · Cochrane Headline outcomes only
  RR 0.68 [0.28, 1.66]
  1 study · 328 participants
  Low

Resilience interventions vs controls

• Psychological interventions to foster resilience in healthcare students 2020 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 362 participants
  Very low

Resilience interventions vs controls

• Psychological interventions to foster resilience in healthcare students 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 332 participants
  Very low

Resilience interventions vs controls

• Psychological interventions to foster resilience in healthcare students 2020 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 420 participants
  Very low

Mucolytic vs placebo

• Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 2721 participants
  Moderate

Copper intrauterine device vs mifepristone (all doses)

Copper intrauterine device may leads to higher specific side effects ‐ lower abdominal pain compared with mifepristone (all doses) (low certainty).

• Interventions for emergency contraception 2019 · Cochrane Headline outcomes only
  RR 73.61 [4.48, 1208.5]
  1 study · 285 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes participants with any complication: up to 3 months following… (very low certainty).

• Glucocorticosteroids for people with alcoholic hepatitis 2019 · Cochrane Headline outcomes only
  RR 1.04 [0.86, 1.27]
  15 studies · 1861 participants
  Very low

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Antibiotic prophylaxis showed no clear difference in symptomatic UTI; antibiotics versus placebo in trials with low risk… compared with surveillance or no treatment (moderate certainty).

• Interventions for primary vesicoureteric reflux 2019 · Cochrane Headline outcomes only
  RR 0.85 [0.4, 1.79]
  3 studies · 943 participants
  Moderate

Intervention not reported

The review found no eligible studies for this question.

• Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Exercise therapy vs psychological treatment

• Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 331 participants
  Moderate

Exercise therapy vs psychological treatment

• Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 287 participants
  Low