Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,372 questions · 3,874 findings · 666 reviews

No studies found 431 · 11.1%GRADE not reported 783 · 20.2%Very low 995 · 25.7%Low 909 · 23.5%Moderate 596 · 15.4%High 160 · 4.1%

Lay health worker‐led psychological interventions vs usual care

Depression symptoms ‐ intermediate term (1 to 6 months post intervention) GHQ‐12a; PHQ‐9d,e,f; self‐reporting questionnaireh (higher score = higher severity) · adults with post‐traumatic stress and CMDs
1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Quality of life ‐ intermediate term (1 to 6 months post intervention) EQ‐5Di; SF‐36c,m; WHOQOL‐BREFe,j,n (higher score = better quality of life) · adults with post‐traumatic stress and CMDs
1 finding from 1 review

Primary health professional‐led psychological interventions vs usual care or no treatment

Severity of PTSD symptoms · adults with post‐traumatic stress or common mental disorders

It is very uncertain whether primary health professional‐led psychological interventions changes PTS symptoms (1 to 6 months post intervention) Harvard Trauma… compared with usual or no care (very low certainty).

1 finding from 1 review

Primary health professional‐led psychological interventions vs usual care or no treatment

Depression symptoms (1 to 6 months post intervention) Hopkins Symptom Checklist ‐ depression (higher score = higher severity) · adults with post‐traumatic stress or common mental disorders

It is very uncertain whether primary health professional‐led psychological interventions changes depression symptoms (1 to 6 months post intervention) Hopkins… compared with usual or no care (very low certainty).

1 finding from 1 review

Primary health professional‐led psychological interventions vs usual care or no treatment

Functional impairment · adults with post‐traumatic stress or common mental disorders

It is very uncertain whether primary health professional‐led psychological interventions changes functional impairment (1 to 6 months post intervention) Locally… compared with usual or no care (very low certainty).

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Functional impairment ‐ not measured · adults with common mental disorders

Lay health worker‐led psychological interventions showed no clear difference in functional impairment/disability ‐ intermediate term (1 to 6 months… compared with usual care (low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months post intervention) Defined by AUDIT score < 8 (RR > 1 denotes higher likelihood of recovery) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical recovery ‐ harmful or dependent alcohol use (1 to 6 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Service utilisation ‐ Unplanned hospitalisation in past 12 months (RR > 1 denotes higher risk of hospitalisation) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes service utilisation ‐ Unplanned hospitalisation in past 12 months… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes adverse events ‐ death in past 12 months (RR > 1 denotes higher risk… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs specialist‐led care

Caregiver burden · people with severe mental disorders

Lay health worker‐ showed no clear difference in caregiver burden symptom severity ‐ immediately post intervention… compared with specialist‐led care (low certainty).

1 finding from 1 review

Endometrial injury vs control

Clinical pregnancy per woman randomised: sensitivity analysis (no high‐risk) · women undergoing assisted reproduction

Endometrial injury showed no clear difference in clinical pregnancy per woman randomised: sensitivity analysis (no… compared with control (low certainty).

1 finding from 1 review