Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Lidocaine vs mexiletine

Adverse events (AEs; adverse drug reaction): atrioventricular block · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): atrioventricular block compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Ventricular fibrillation · patients with myocardial infarction

It is very uncertain whether lidocaine changes ventricular fibrillation compared with propafenone (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Neuropsychiatric adverse event · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): neuropsychiatric… compared with propafenone (very low certainty).

1 finding from 1 review

Lidocaine vs amiodarone

Ventricular fibrillation · patients with myocardial infarction

It is very uncertain whether lidocaine changes ventricular fibrillation compared with amiodarone (very low certainty).

1 finding from 1 review

Gabapentin vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with pain in Guillain‐Barré syndrome

It is very uncertain whether gabapentin changes pain score (numerical rating scale of 0 to 10: 0 = no pain, 10 =… compared with placebo (very low certainty).

1 finding from 1 review

Gabapentin vs placebo

Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) · patients with pain in Guillain‐Barré syndrome

It is very uncertain whether gabapentin changes sedation score (numerical rating scale of 1 to 6: 0 = anxious,… compared with placebo (very low certainty).

1 finding from 1 review