Head circumference (mm) · pregnant women and their infants..
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Head circumference: WMD 0.05 (95% CI -0.24 to 0.34), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Gestational age at birth (weeks) · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Mean gestational age at delivery: WMD 0.17 (95% CI -0.16 to 0.51), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD 0.17 [-0.16, 0.51]
2 studies
GRADE not reported
Birth length · pregnant women and their infants..
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Birth length: WMD 0.19 (95% CI -0.26 to 0.65), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Small‐for‐gestational age · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Small for gestational age: RR 0.67 (95% CI 0.40 to 1.11), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Birthweight (g) · pregnant women and their infants..
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Birth weight: WMD 130.9 (95% CI 75.1 to 186.7), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
Head circumference (mm) · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Head circumference at birth: WMD 0.43 (95% CI 0.06 to 0.79), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
WMD 0.43 [0.06, 0.79]
2 studies
GRADE not reported
Low birthweight · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Low birth weight: RR 0.4 (95% CI 0.23 to 0.71), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
Gestational diabetes · pregnant women and their infants..
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Gestational diabetes: OR 0.67 (95% CI 0.53 to 0.85), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Birth length · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Birth length: WMD 0.97 (95% CI -0.41 to 2.34), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
WMD 0.97 [-0.41, 2.34]
2 studies
GRADE not reported
Maternal vitamin D concentration at term (25‐hydroxyvitamin D) (nmol/L) (ALL) · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Maternal vitamin D concentrations at term: WMD 47.08 (95% CI 23.76 to 70.39), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
WMD 47.08 [23.76, 70.39]
4 studies
GRADE not reported
Clinic-based dental care utilization · Alaska children
The PDHA program was projected to increase clinic-based dental care utilization from 75% to 90%, without a GRADE rating.
1 finding from 1 review
Dental caries · Alaska children below age 5 years
The PDHA program was projected to reduce mean DMFT in children below age 5 from 7.4 to 4.9, without a GRADE rating.
1 finding from 1 review
Mean DMFT 7.4 to 4.9
1 study
GRADE not reported
School-based oral health promotion services · Alaska children
The PDHA program was projected to raise school-based oral health promotion service receipt from 53% to more than 90%, without a GRADE rating.
1 finding from 1 review
Significant caries index · Alaska children
The PDHA program was projected to reduce the SiC index 50% from 12.3 to 6.1 for children, without a GRADE rating.
1 finding from 1 review
Significant caries index · Alaska children aged 12 years
The PDHA program was projected to reduce the SiC index 70% from 10.5 to 3.3 for 12-year-olds, without a GRADE rating.
1 finding from 1 review
Infant dental caries · Pregnant Alaska Native women and their infants
No infant caries outcomes were assessed because the proposed randomized trial was discontinued.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Clinical failure (post dislodgement) · Participants with endodontically-treated permanent premolars restored with a carbon-fibre post (Category III)
Direct composite restoration (final restoration) showed no clear difference in clinical failure (post dislodgement) compared with full-coverage metal-ceramic crown; GRADE not reported.
1 finding from 1 review
Gingivitis · Adults, 16 years and older (dentate)
It is very uncertain whether interdental brushing plus toothbrushing changes gingivitis (gingival index) compared with toothbrushing alone (very low certainty).
MD -0.53 [-0.83, -0.23]
1 study · 62 participants
Very low
MD -0.05 [-0.13, 0.03]
1 study · 31 participants
Very low
MD -0.53 [-0.83, -0.23]
1 study · 62 participants
Very low
Plaque · Adults, 16 years and older (dentate)
Interdental brushing plus toothbrushing may leads to lower plaque compared with toothbrushing alone (low certainty).
Gingivitis · Adults, 16 years and older (dentate)
Interdental brushing plus toothbrushing may leads to lower gingivitis (proportion of bleeding sites) compared with flossing plus toothbrushing (low certainty).
MD -0.06 [-0.08, -0.03]
6 studies · 234 participants
Low
SMD -0.40 [-0.70, -0.11]
3 studies · 183 participants
Low
SMD -0.53 [-0.81, -0.24]
7 studies · 326 participants
Low
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