Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,372 questions · 3,874 findings · 666 reviews

No studies found 431 · 11.1%GRADE not reported 783 · 20.2%Very low 995 · 25.7%Low 909 · 23.5%Moderate 596 · 15.4%High 160 · 4.1%

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving control of inflammation (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving steroid‐sparing control (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Non‐biologic disease‐modifying antirheumatic drugs (DMARDs) vs steroids

Proportion of participants achieving a 2‐line improvement in visual acuity (Snellen chart) (higher scores indicate better vision) · NIIPPU

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

Methotrexate probably leads to higher proportion of participants achieving control of inflammation§… compared with mycophenolate (moderate certainty).

1 finding from 1 review

Maternal education attainment vs Not applicable (single-group prevalence)

Secondary/higher maternal education prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

About 45% of children with caries in LMICs had mothers with secondary or higher education (pooled prevalence 0.450, 95% CI 0.330 to 0.572; 7 studies; not GRADE-rated).

1 finding from 1 review

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

Serum high-sensitivity C-reactive protein (hs-CRP) · Patients with cardiovascular disease and chronic periodontitis
1 finding from 1 review

Socioeconomic status category vs Not applicable (single-group prevalence)

High SES prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

About 25% of children with caries in LMICs were of high SES (pooled prevalence 0.245, 95% CI 0.162 to 0.339; 5 studies; not GRADE-rated).

1 finding from 1 review

Intervention not reported

Cohort studies ‐ autism risk (moderate/high), MMR · children 9 months to 15 years old

The intervention may leads to lower cohort studies ‐ autism risk (moderate/high), MMR (low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (continuous) HDRS where possible; higher scores indicate greater symptomology · adults with Major Depressive Disorder
1 finding from 1 review

n3PUFAs vs placebo

Quality of lifeValidated quality of life scales as used by authors, CGI (7‐point scale) where possible, higher scores indicate poorer quality of life · adults with Major Depressive Disorder
1 finding from 1 review

Interventions delivered by dental professionals vs control

Smoking cessation · participants who used tobacco products

It is very uncertain whether interventions delivered by dental professionals changes behavioural support from dental professional at high school/college… compared with control (very low certainty).

1 finding from 1 review

Supported discharge and multidisciplinary home rehabilitation vs (Optimised) usual care

'Poor outcome' (dead or moved to higher level of care or unable to walk) · Older people undergoing hip fracture aftercare

It is very uncertain whether supported discharge and multidisciplinary home rehabilitation changes 'Poor outcome' (dead or moved to higher level of care or unable to… compared with usual care: mainly (very low certainty).

1 finding from 1 review

Supported discharge and multidisciplinary home rehabilitation vs (Optimised) usual care

Permanent move to higher level of care (hostel, nursing home, sheltered housing) · Older people undergoing hip fracture aftercare

It is very uncertain whether supported discharge and multidisciplinary home rehabilitation changes permanent move to higher level of care (hostel, nursing home,… compared with usual care: mainly (very low certainty).

1 finding from 1 review