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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
793 questions in 32 reviews · Periodontology
current versionsNo studies 148 · 18.7%Ungraded 429 · 54.1%Very low 137 · 17.3%Low 53 · 6.7%Moderate 14 · 1.8%High 12 · 1.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Azithromycin + SRP vs SRP Percentage of closed pockets · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -2.90 [-13.91, 8.11] | 1 study · 40 participants | Ungraded |
Doxycycline + SRP vs SRP Probing pocket depth · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.10 [-0.29, 0.50] | 2 studies · 43 participants | Ungraded |
Doxycycline + SRP vs Metronidazole + SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clindamycin + SRP vs Doxycycline + SRP Antimicrobial resistance · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Amoxicillin + metronidazole + SRP vs SRP Probing pocket depth · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.47 [-0.68, -0.26] | 6 studies · 215 participants | Ungraded |
Azithromycin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -3.32 [-6.23, -0.42] | 6 studies · 228 participants | Ungraded |
Doxycycline + SRP vs SRP Probing pocket depth · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.00 [-1.78, -0.22] | 1 study · 22 participants | Very low |
Doxycycline + SRP vs Metronidazole + SRP Probing pocket depth · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.38 [0.00, 0.76] | 3 studies · 75 participants | Ungraded |
Clindamycin + SRP vs Metronidazole + SRP Probing pocket depth · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.14 [-0.82, 0.54] | 1 study · 26 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.00 [-0.09, 0.09] | 1 study · 21 participants | Very low |
Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.00 [-0.26, 0.26] | 1 study · 46 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs SRP Probing pocket depth · Adults with chronic periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.00 [-0.19, 0.19] | 1 study · 21 participants | Ungraded |
Doxycycline + SRP vs Metronidazole + SRP Adverse events · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported adverse events | NR | No studies |
Doxycycline + SRP vs Metronidazole + SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.05 [-0.22, 0.12] | 1 study · 22 participants | Ungraded |
Metronidazole + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -6.90 [-22.10, 8.30] | 1 study · 22 participants | Very low |
Doxycycline + SRP vs SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.61 [-1.14, -0.08] | 3 studies · 65 participants | Ungraded |
Tetracycline + SRP vs SRP Probing pocket depth · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clindamycin + SRP vs Doxycycline + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.90 [-1.62, -0.18] | 1 study · 23 participants | Very low |
Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.60 [-0.86, -0.34] | 1 study · 46 participants | Ungraded |
Clindamycin + SRP vs Metronidazole + SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Tetracycline + SRP vs SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.90 [-2.17, -1.63] | 1 study · 26 participants | Ungraded |
Clindamycin + SRP vs SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.30 [-2.14, -0.46] | 1 study · 21 participants | Ungraded |
Amoxicillin + metronidazole + SRP vs SRP Probing pocket depth · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.18 [-0.33, -0.04] | 15 studies · 562 participants | Ungraded |
Doxycycline + SRP vs Amoxicillin + metronidazole + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.17 [-1.28, 1.62] | 1 study · 20 participants | Ungraded |
Illicit drug use vs People who do not use drugs DMFT index (dental caries experience) · People who use drugs (PWUD): methamphetamine, heroin, opiate, cannabis and cocaine users Dental caries and periodontal disease among people who use drugs: a systematic review and meta-analysis. (2020) | OR 4.11 [2.07, 8.15] | 7 studies | Ungraded |
Clarithromycin + SRP vs SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.65 [-1.20, -0.09] | 2 studies · 77 participants | Ungraded |
Tetracycline + SRP vs SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -2.30 [-2.50, -2.10] | 1 study · 26 participants | Very low |
Amoxicillin + metronidazole + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -2.05 [-2.98, -1.11] | 13 studies · 460 participants | Ungraded |
Clindamycin + SRP vs Doxycycline + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.40 [-1.15, 0.35] | 1 study · 23 participants | Ungraded |
Clindamycin + SRP vs SRP Percentage of closed pockets · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clindamycin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Metronidazole + SRP vs Amoxicillin + metronidazole + SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.06 [-1.06, 1.18] | 1 study · 22 participants | Ungraded |
Doxycycline + SRP vs Amoxicillin + metronidazole + SRP Probing pocket depth · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.14 [-0.12, 0.40] | 2 studies · 50 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs Tetracycline + SRP Adverse events · Adults with aggressive periodontitis Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | The only included trial (Abu Fanas 1991) reported there were no adverse events. | 1 study · 8 participants | Ungraded |
Cefixime + SRP vs SRP Clinical attachment level (CAL) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.19 [-0.77, 0.39] | 1 study · 60 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs SRP Probing pocket depth · Adults with chronic periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.10 [-0.17, 0.37] | 1 study · 21 participants | Very low |
Amoxicillin + clavulanate + SRP vs SRP Clinical attachment level (CAL) · Adults with chronic periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.10 [-0.45, 0.65] | 1 study · 21 participants | Ungraded |
Clindamycin + SRP vs SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Metronidazole + SRP vs SRP Percentage of closed pockets · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -12.20 [-29.23, 4.83] | 1 study · 22 participants | Very low |
Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP Probing pocket depth · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.20 [-0.35, -0.05] | 1 study · 46 participants | Ungraded |
Doxycycline + SRP vs Metronidazole + SRP Antimicrobial resistance · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Levofloxacin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.38 [-3.30, 0.54] | 2 studies · 131 participants | Ungraded |
Clarithromycin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -4.70 [-8.42, -0.98] | 1 study · 40 participants | Ungraded |
Azithromycin + SRP vs SRP Percentage of closed pockets · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 2.50 [-10.19, 15.19] | 1 study · 40 participants | Very low |
Amoxicillin + clavulanate + SRP vs SRP Adverse events · Adults with chronic periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included study reported diarrhoea in 2 participants from both groups. | 1 study · 21 participants | Very low |
Clindamycin + SRP vs Metronidazole + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.40 [-0.22, 1.02] | 1 study · 26 participants | Ungraded |
Clindamycin + SRP vs Doxycycline + SRP Probing pocket depth · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.80 [-1.58, -0.02] | 1 study · 23 participants | Very low |
Amoxicillin + metronidazole + SRP vs SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.47 [-0.90, -0.05] | 2 studies · 389 participants | Very low |
Levofloxacin + SRP vs SRP Probing pocket depth · Adults with chronic periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.23 [-1.46, -1.00] | 2 studies · 131 participants | Ungraded |
Clindamycin + SRP vs SRP Adverse events · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included study has not reported adverse events | NR | No studies |