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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,280 questions in 114 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 37.5%Ungraded 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cycled inhaled tobramycin (TNS) vs culture‐based TNS FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Cycled inhaled tobramycin (TNS) vs culture‐based TNS Growth and nutritional status: mean 70‐week change from baseline in weight (kg) and height (cm) · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 304 participants | Moderate |
Cycled inhaled tobramycin (TNS) vs culture‐based TNS Frequency of infective pulmonary exacerbations: proportion of participants with one or more pulmonary exacerbations (any severity) · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 0.75 | 1 study · 304 participants | Moderate |
Inhaled tobramycin (TNS) vs placebo FEV1 · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 22 participants | Very low |
Cycled inhaled tobramycin (TNS) vs culture‐based TNS Isolation of other micro‐organisms from the respiratory tract: proportion of participants with new isolates of Stenotrophomonas maltophilia · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 1.18 [0.65, 2.12] | 1 study · 279 participants | Moderate |
Cycled inhaled tobramycin (TNS) vs culture‐based TNS Adverse effects of antibiotics: proportion of participants with one or more serious adverse events · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 0.85 | 1 study · 304 participants | Moderate |
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy Eradication of P aeruginosa from the respiratory tract: proportion of participants with one or more isolates of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy FEV1: mean 70‐week % change in FEV1 (% predicted) · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 143 participants | Low |
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy Growth and nutritional status: mean 70‐week change from baseline in weight (kg) and height (cm) · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 304 participants | Moderate |
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy Frequency of infective pulmonary exacerbations: proportion of participants with one or more pulmonary exacerbations (any severity) · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 1.49 [0.95, 2.33] | 1 study · 304 participants | Moderate |
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy Isolation of other micro‐organisms from the respiratory tract: proportion of participants with new isolates of Stenotrophomonas maltophilia · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 1.2 [0.66, 2.16] | 1 study · 279 participants | Moderate |
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy Adverse effects of antibiotics: proportion of participants with one or more serious adverse event · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 1.54 [0.93, 2.57] | 1 study · 304 participants | Moderate |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) Eradication of P aeruginosa from the respiratory tract: proportion with positive respiratory culture for P aeruginosa · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 0.43 [0.15, 1.23] | 1 study · 58 participants | Very low |
Inhaled tobramycin (TNS) vs placebo FVC · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 22 participants | Very low |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) FEV1: change from baseline (% predicted) · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 58 participants | Very low |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) Growth and nutritional status: BMI and weight z score · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 58 participants | Very low |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 58 participants | Very low |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) Adverse effects of antibiotics: severe cough · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 0.32 [0.01, 8.24] | 1 study · 58 participants | Very low |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin Eradication of P aeruginosa from the respiratory tract: proportion with positive respiratory culture for P aeruginosa · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | OR 1.11 [0.64, 1.92] | 1 study · 223 participants | Low |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin FEV1: relative change in % predicted FEV1 from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin Growth and nutritional status · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled tobramycin (TNS) vs placebo Growth and nutritional status: change in weight (kg) from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 205 participants | Moderate |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin Adverse effects of antibiotics: leading to trial discontinuation · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 223 participants | Moderate |
Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo Eradication of P aeruginosa from the respiratory tract: number of participants eradicated after three month treatment phase · children with cystic fibrosis and a new culture positive for P aeruginosa Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | RR 1.01 [0.75, 1.35] | 1 study · 91 participants | Low |
Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo FEV1: mean change in FEV1 % predicted · children with cystic fibrosis and a new culture positive for P aeruginosa Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 132 participants | Low |
Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo FVC: mean change in FVC % predicted · children with cystic fibrosis and a new culture positive for P aeruginosa Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 18 participants | Low |
Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo Growth and nutritional status: mean change in weight (kg) from baseline · children with cystic fibrosis and a new culture positive for P aeruginosa Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 221 participants | Moderate |
Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo Frequency of infective pulmonary exacerbations: number of participants experiencing an exacerbation by the end of the study · children with cystic fibrosis and a new culture positive for P aeruginosa Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | RR 0.75 [0.56, 1] | 1 study · 221 participants | Moderate |
Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo Isolation of other micro‐organisms from the respiratory tract: number of participants with a positive result for other organisms. · children with cystic fibrosis and a new culture positive for P aeruginosa Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 221 participants | Moderate |
Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo Adverse effects of antibiotics: number of participants experiencing any adverse event · children with cystic fibrosis and a new culture positive for P aeruginosa Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | RR 1.05 [0.96, 1.14] | 1 study · 221 participants | Moderate |
Inhaled tobramycin (TNS) vs placebo Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment Eradication of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment FEV1 · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment Growth and nutritional status · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment Adverse effects of antibiotics · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 26 participants | Very low |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI Eradication of P aeruginosa from the respiratory tract: proportion of participants with a negative culture for PA during the 28 days following treatment · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | 1 study · 139 participants | Very low |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI FEV1 % predicted · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI FVC % predicted · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled tobramycin (TNS) vs placebo Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI Growth and nutritional status · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI Frequency of infective pulmonary exacerbations · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |