Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

150 questions · 164 findings · 14 reviews

No studies found 32 · 19.5%GRADE not reported 35 · 21.3%Very low 62 · 37.8%Low 21 · 12.8%Moderate 14 · 8.5%High 0 · 0%

Doxycycline vs tetracycline

Treatment failure · adults with scrub typhus

It is very uncertain whether doxycycline changes treatment failure compared with tetracycline (very low certainty).

1 finding from 1 review

Doxycycline vs tetracycline

Resolution of fever within 48 hours · adults with scrub typhus

Doxycycline showed no clear difference in resolution of fever within 48 hours compared with tetracycline (low certainty).

1 finding from 1 review

10% CP gel in tray vs 7.5% HP gel in tray

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 10% CP gel in tray changes tooth whitening - assessed by the dentist compared with 7.5% HP gel in tray (very low certainty).

1 finding from 1 review

10% CP gel in tray vs 6% HP gel in tray

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 10% CP gel in tray changes tooth whitening - assessed by the dentist compared with 6% HP gel in tray (very low certainty).

2 findings from 1 review

17% CP gel in tray vs 10% CP gel in tray

Tooth whitening - reported by the patient · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 17% CP gel in tray changes tooth whitening - reported by the patient compared with 10% CP gel in tray (very low certainty).

1 finding from 1 review

5.9% HP strip vs 5.9% HP paint-on gel

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

5.9% HP strip led to higher tooth whitening - assessed by the dentist compared with 5.9% HP paint-on gel; GRADE not reported.

2 findings from 1 review

5% CP gel in tray vs 10% CP gel in tray

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 5% CP gel in tray changes tooth whitening - assessed by the dentist compared with 10% CP gel in tray (very low certainty).

1 finding from 1 review

18% CP paint-on gel vs 16.4% CP paint-on gel

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 18% CP paint-on gel changes tooth whitening - assessed by the dentist compared with 16.4% CP paint-on gel (very low certainty).

1 finding from 1 review

16% CP gel in tray + ACP vs 16% CP gel in tray

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

16% CP gel in tray + ACP may leads to higher tooth whitening - assessed by the dentist compared with 16% CP gel in tray (low certainty).

1 finding from 1 review

6% HP strip vs 5% CP gel in tray + 5% KN

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 6% HP strip changes tooth whitening - assessed by the dentist compared with 5% CP gel in tray + 5% KN (very low certainty).

1 finding from 1 review

4% SHMP chewing gum vs placebo

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 4% SHMP chewing gum changes tooth whitening - assessed by the dentist compared with placebo (very low certainty).

1 finding from 1 review

10% HP strip vs 2% HP mouthwash/rinse

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

10% HP strip led to lower tooth whitening - assessed by the dentist compared with 2% HP mouthwash/rinse; GRADE not reported.

1 finding from 1 review

6% / 5.3% HP strip vs placebo

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

6% / 5.3% HP strip may leads to higher tooth whitening - assessed by the dentist compared with placebo (low certainty).

1 finding from 1 review

6.5% HP strip vs 15% CP gel in tray

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 6.5% HP strip changes tooth whitening - assessed by the dentist compared with 15% CP gel in tray (very low certainty).

1 finding from 1 review