Adverse events · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.
1 finding from 1 review
All three included trials (Matarazzo 2008; Silva 2011; Xajigeorgiou 2006) reported adverse events in both MTZ + SRP and AMOX + MTZ + SRP groups (nausea, vomiting, diarrhoea, headache, metallic taste, irritability, mild…
3 studies · 84 participants
GRADE not reported
Adverse events · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.
1 finding from 1 review
Patient-reported quality of life changes · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower percentage of closed pockets compared with SRP; GRADE not reported.
3 findings from 1 review
MD -13.90 [-24.16, -3.64]
1 study · 44 participants
GRADE not reported
MD -16.20 [-25.87, -6.53]
1 study · 44 participants
Very low
MD -10.05 [-18.78, -1.32]
2 studies · 73 participants
GRADE not reported
Probing pocket depth · Adults with aggressive periodontitis
It is very uncertain whether clindamycin + SRP changes probing pocket depth compared with SRP (very low certainty).
3 findings from 1 review
MD -1.80 [-2.47, -1.13]
1 study · 21 participants
Very low
MD -1.10 [-1.94, -0.26]
1 study · 21 participants
GRADE not reported
MD 0.10 [-0.55, 0.75]
1 study · 21 participants
GRADE not reported
Adverse events · Adults with chronic periodontitis
Moxifloxacin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.
1 finding from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether azithromycin + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.59 [-1.27, 0.08]
2 studies · 110 participants
Very low
MD -0.43 [-0.77, -0.10]
7 studies · 258 participants
GRADE not reported
MD -0.51 [-0.83, -0.19]
6 studies · 216 participants
GRADE not reported
Patient-reported quality of life changes · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.
1 finding from 1 review
Adverse events · Adults with chronic periodontitis
Levofloxacin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.
1 finding from 1 review
Percentage of closed pockets · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Probing pocket depth · Adults with chronic periodontitis
Moxifloxacin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
2 findings from 1 review
Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with chronic periodontitis
Cefixime + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.
1 finding from 1 review
The only included trial (Dukic 2016) reported nausea, dizziness and/or anorexia in the cefixime + SRP group.
1 study · 60 participants
GRADE not reported
Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis
Cefixime + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.
1 finding from 1 review
Antimicrobial resistance · Adults with aggressive periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Antimicrobial resistance · Adults with chronic periodontitis
The review found no eligible studies for this question.
1 finding from 1 review
Clinical attachment level (CAL) · Adults with chronic periodontitis
Moxifloxacin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
2 findings from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
2 findings from 1 review
Percentage of closed pockets · Adults with chronic periodontitis
The review found no eligible studies for this question.
1 finding from 1 review