Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

107 questions · 107 findings · 15 reviews

No studies found 14 · 13.1%GRADE not reported 17 · 15.9%Very low 48 · 44.9%Low 24 · 22.4%Moderate 2 · 1.9%High 2 · 1.9%

HALOPERIDOL vs OTHER ANTIPSYCHOTICS

Specific behaviour ‐ threat or injury to self or others average change score (ABS, high = worse) at 2 hours · people with long‐term aggression in psychosis

HALOPERIDOL leads to lower specific behaviours ‐ threat or injury to others/self compared with OTHER ANTIPSYCHOTICS (high certainty).

1 finding from 1 review

Pericyazine vs atypical antipsychotics

Leaving the study early for specific reasons · patients with schizophrenia

It is very uncertain whether pericyazine changes leaving the study early for specific reasons compared with atypical antipsychotic (very low certainty).

1 finding from 1 review

Pericyazine vs Typical antipsychotics

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether pericyazine changes adverse events ‐ for specific reasons ‐ Extrapyramidal side effect compared with typical antipsychotic (very low certainty).

1 finding from 1 review

Pericyazine vs Typical antipsychotics

Leaving the study early for specific reasons · patients with schizophrenia

It is very uncertain whether pericyazine changes leaving the study early for specific reasons compared with typical antipsychotic (very low certainty).

1 finding from 1 review