Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
Only one in vitro study assessed a Self-Etch adhesive with the biological ACAD protocol; it was insufficient for network meta-analysis, so no pooled effect estimate is available (ungraded).
1 finding from 1 review
Arrest of dentine caries · Children with dentine caries in primary and permanent teeth
Professionally applied 38% silver diamine fluoride arrested about two-thirds of active dentine caries surfaces in children (pooled proportion 65.9%, 95% CI 41.2% to 90.7%; 5 studies); certainty was not GRADE-rated and heterogeneity was very high (I2=96%).
1 finding from 1 review
Visual marginal discrepancy (3 years) · Patients receiving single crowns and FDPs; split-mouth
Low-gold (Midas) or silver-palladium (Albacast) alloy FDP showed no clear difference in visual marginal discrepancy (3 years) compared with high-gold content control alloy (JS C) FDP; GRADE not reported.
1 finding from 1 review
Arrest of dentine caries · Children with active dentine caries
One trial found a single application of 12% silver diamine fluoride did not arrest dentine caries; ungraded.
1 finding from 1 review
Restoration survival · Patients receiving crowns and FDPs; split-mouth, 10-year
Alternative alloy FDP (e.g., Ceramalloy II / base-metal /… led to higher restoration survival (Ceramalloy II versus Olympia) compared with high-gold content control alloy FDP (Olympia); GRADE not reported.
1 finding from 1 review
OR 3.5 [1.4, 8.7]
1 study
GRADE not reported
Laboratory cost per unit · Patients receiving crowns and FDPs; split-mouth, 10-year
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
The direct estimate found no statistically significant difference in oral health-related quality of life between placebo and silver diamine fluoride.
2 findings from 1 review
Oral health-related quality of life · Children with dental caries
The direct estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment plus fluoride varnish and silver diamine fluoride plus fluoride varnish.
2 findings from 1 review
Oral health-related quality of life · Children with dental caries
The network estimate found no statistically significant difference in oral health-related quality of life between atraumatic restorative treatment and silver diamine fluoride.
2 findings from 1 review
Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars
A single (one-time) SDF application did not significantly arrest caries (pooled ES -0.09, 95% CI -0.48 to 0.29; ungraded).
1 finding from 1 review
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 12 months, the Hall technique had significantly higher treatment success than SMART (OR 4.36; moderate certainty).
2 findings from 1 review
OR 4.36 [1.13, 16.77]
43 studies
Moderate
OR 5.61 [1.36, 23.08]
44 studies
Moderate
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 12 months, the Hall technique had significantly higher treatment success than SDF (OR 3.23; moderate certainty).
2 findings from 1 review
OR 3.23 [1.13, 9.22]
43 studies
Moderate
OR 4.87 [1.23, 19.30]
44 studies
Moderate
Incidence of VAP · Critically ill patients receiving mechanical ventilation in ICU
1 finding from 1 review
All‐cause mortality · Critically ill patients receiving mechanical ventilation in ICU
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study (45 children), 4 applications of 38% SDF at 1-monthly intervals resulted in fewer surfaces with active caries compared with 2 applications at 6-monthly intervals (MD 1.04 surfaces, 95% CI 0.23 to 1.85), and…
4 studies · 1360 participants
Very low
Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review
Secondary prevention of caries · Children and adults (with or without carious lesions)
It is very uncertain whether SDF (given at a particular frequency, concentration, or duration) changes secondary prevention of caries compared with SDF (given at a different frequency, concentration, or duration) (very low certainty).
1 finding from 1 review
Primary caries prevention · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
1 study (203 children) reported that black or brown staining on treated lesions was commonly found in both groups, with little or no difference according to whether SDF treatment was given in 3 applications at…
3 studies · 1121 participants
Very low