Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

127 questions · 128 findings · 30 reviews · Pregnancy and Childbirth

No studies found 31 · 24.2%GRADE not reported 11 · 8.6%Very low 17 · 13.3%Low 43 · 33.6%Moderate 19 · 14.8%High 7 · 5.5%

Direct estimation using calibrated drapes vs indirect estimation using gravimetric technique

Use of therapeutic uterotonics · women undergoing vaginal birth

Direct measurement using calibrated drapes showed no clear difference in use of therapeutic uterotonics compared with indirect estimation using gravimetric technique (high certainty).

1 finding from 1 review

Selective vs routine episiotomy: all vaginal births where operative vaginal delivery was not anticipated

Severe perineal/vaginal trauma · Women in labour where operative delivery was not anticipated. (Women were above 16 years old and between 28 gestational weeks and full…

Selective may leads to lower severe perineal/vaginal trauma compared with routine episiotomy: all vaginal births where operative vaginal… (low certainty).

1 finding from 1 review

Selective vs routine episiotomy: all vaginal births where operative vaginal delivery was not anticipated

Perineal infection · Women in labour where operative delivery was not anticipated. (Women were above 16 years old and between 28 gestational weeks and full…

Selective showed no clear difference in perineal infection compared with routine episiotomy: all vaginal births where operative vaginal… (low certainty).

1 finding from 1 review

Selective vs routine episiotomy: all vaginal births where operative vaginal delivery was not anticipated

Women with moderate or severe pain (measured by visual analogue scale) · Women in labour where operative delivery was not anticipated. (Women were above 16 years old and between 28 gestational weeks and full…

It is very uncertain whether selective changes women with moderate or severe pain (measured by visual analogue scale) compared with routine episiotomy: all vaginal births where operative vaginal… (very low certainty).

1 finding from 1 review

Selective vs routine episiotomy: all vaginal births where operative vaginal delivery was not anticipated

Women with long‐term dyspareunia (≥ 6 months) · Women in labour where operative delivery was not anticipated. (Women were above 16 years old and between 28 gestational weeks and full…

Selective showed no clear difference in women with long‐term dyspareunia (≥ 6 months) compared with routine episiotomy: all vaginal births where operative vaginal… (moderate certainty).

1 finding from 1 review

Selective vs routine episiotomy: all vaginal births where operative vaginal delivery was not anticipated

Women with long‐term urinary incontinence (≥ 6 months) · Women in labour where operative delivery was not anticipated. (Women were above 16 years old and between 28 gestational weeks and full…

Selective showed no clear difference in women with long‐term urinary incontinence (≥ 6 months) compared with routine episiotomy: all vaginal births where operative vaginal… (low certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Neural tube defects (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate leads to lower neural tube defects (All) compared with no intervention, placebo or other micronutrients without folate… (high certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Miscarriage · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in miscarriage (All) compared with no intervention, placebo or other micronutrients without folate… (moderate certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Cleft lip (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in cleft lip (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).

1 finding from 1 review