Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,368 questions · 1,413 findings · 89 reviews · Common Mental Disorders

No studies found 232 · 16.4%GRADE not reported 82 · 5.8%Very low 395 · 28%Low 331 · 23.4%Moderate 341 · 24.1%High 32 · 2.3%

Switching to mianserin (60 mg/d) vs continuing on current antidepressant (fluoxetine 20 mg/d)

Depressive symptoms · treatment‐resistant depression in adults

Switching to mianserin (60 mg/d) showed no clear difference in depressive symptoms (HAM‐D) Scale from: 0 to 54 (worse) compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Improvement in depression at 6‐12 weeks: HAM‐D score (dichotomized) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes improvement in depression at 6‐12 weeks: HAM‐D score (dichotomized) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes improvement in depression at 6‐12 weeks: CGI‐I (score of 1 or 2) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

> 50% reduction in depressive symptoms · depression in adults

It is very uncertain whether S‐adenosyl methionine as monotherapy changes proportions of participants responding to treatment ≥ 50% reduction… compared with tricyclic antidepressant agent (very low certainty).

1 finding from 1 review