Findings

What do systematic reviews say?

125 questions · 125 findings · 7 reviews

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No studies found 44 · 35.2%GRADE not reported 1 · 0.8%Very low 52 · 41.6%Low 21 · 16.8%Moderate 7 · 5.6%High 0 · 0%

Opioids vs phenobarbital

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs phenobarbital

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs phenobarbital

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 166 participants
Low

Opioids vs phenobarbital

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 349 participants
Low

Opioids vs phenobarbital

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Low

Levetiracetam vs phenobarbital

50% or greater reduction in seizure frequency · patients with AD and epileptic seizures

It is very uncertain whether levetiracetam changes reduction in seizure frequency of 50% or more compared with phenobarbital (very low certainty).

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
RR 1.11 [0.78, 1.56]
1 study · 66 participants
Very low

Levetiracetam vs phenobarbital

Proportion with seizure freedom in dominantly inherited AD · patients with AD and epileptic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Levetiracetam vs phenobarbital

Change in cognition · patients with AD and epileptic seizures

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Very low

Levetiracetam vs phenobarbital

Change in neuropsychiatric symptoms · patients with AD and epileptic seizures

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Very low

Levetiracetam vs phenobarbital

Improvement in quality of life · patients with AD and epileptic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Lamotrigine vs phenobarbital

Seizure freedom · patients with AD and epileptic seizures

It is very uncertain whether lamotrigine changes proportion with seizure freedom compared with phenobarbital (very low certainty).

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
RR 0.84 [0.35, 2.02]
1 study · 57 participants
Very low

Lamotrigine vs phenobarbital

Proportion with adverse events · patients with AD and epileptic seizures

It is very uncertain whether lamotrigine changes proportion with adverse events compared with phenobarbital (very low certainty).

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
RR 0.68 [0.3, 1.53]
1 study · 57 participants
Very low

Lamotrigine vs phenobarbital

50% or greater reduction in seizure frequency · patients with AD and epileptic seizures

It is very uncertain whether lamotrigine changes reduction in seizure frequency of 50% or more compared with phenobarbital (very low certainty).

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
RR 0.91 [0.6, 1.38]
1 study · 57 participants
Very low

Lamotrigine vs phenobarbital

Proportion with seizure freedom in dominantly inherited AD · patients with AD and epileptic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Lamotrigine vs phenobarbital

Change in cognition · patients with AD and epileptic seizures

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Very low

Lamotrigine vs phenobarbital

Change in neuropsychiatric symptoms · patients with AD and epileptic seizures

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Very low

Lamotrigine vs phenobarbital

Improvement in quality of life · patients with AD and epileptic seizures

The review found no eligible studies for this question.

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Levetiracetam vs phenobarbital

Seizure freedom · patients with AD and epileptic seizures

It is very uncertain whether levetiracetam changes proportion with seizure freedom compared with phenobarbital (very low certainty).

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
RR 1.01 [0.47, 2.19]
1 study · 66 participants
Very low

Levetiracetam vs phenobarbital

Proportion with adverse events · patients with AD and epileptic seizures

It is very uncertain whether levetiracetam changes proportion with adverse events compared with phenobarbital (very low certainty).

1 finding from 1 review

Treatment of epilepsy for people with Alzheimer's disease 2021 · Cochrane Headline outcomes only
RR 0.44 [0.18, 1.07]
1 study · 66 participants
Very low

Benzodiazepines vs phenobarbital (as active placebo)

Adverse effect: extrapyramidal symptoms ‐ not reported · patients with antipsychotic‐induced tardive dyskinesia

The review found no eligible studies for this question.

1 finding from 1 review

Benzodiazepines for antipsychotic‐induced tardive dyskinesia 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found