Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

241 questions · 264 findings · 24 reviews

No studies found 84 · 31.8%GRADE not reported 5 · 1.9%Very low 83 · 31.4%Low 64 · 24.2%Moderate 21 · 8%High 7 · 2.7%

Diclofenac vs opioid

Nausea and vomiting · children with acute postoperative pain

Diclofenac probably leads to lower nausea, vomiting, or both during study period № of participants: 463… compared with opioids (moderate certainty).

1 finding from 1 review

Diclofenac vs opioid

Any bleeding during study period № of participants: 100(2 RCTs)d · children with acute postoperative pain

Diclofenac probably leads to higher any bleeding during study period № of participants: 222 (2 RCTs) compared with opioids (moderate certainty).

1 finding from 1 review

Tramadol vs other opioids

Outcomesa · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs other opioids

Physical function · patients with osteoarthritis

Tramadol alone probably leads to higher physical function compared with other opioids (moderate certainty).

1 finding from 1 review

Tramadol vs other opioids

Number of participants reporting an adverse event · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any adverse event compared with other opioids (very low certainty).

1 finding from 1 review

Tramadol vs other opioids

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol alone may leads to higher number of participants who withdrew due to adverse events compared with other opioids (low certainty).

1 finding from 1 review

Tramadol vs other opioids

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with other opioids (very low certainty).

1 finding from 1 review