Findings

What do systematic reviews say?

103 questions · 111 findings · 10 reviews · Oral and maxillofacial surgery

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No studies found 13 · 11.7%GRADE not reported 75 · 67.6%Very low 21 · 18.9%Low 2 · 1.8%Moderate 0 · 0%High 0 · 0%

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

Quality of life · People with established (manifest) MRONJ

1 finding from 1 review

Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
6 months
QoL measured with the Duke Health Profile; only within-group comparisons were provided; no score values, so a between-group analysis was not possible.
1 study
GRADE not reported

Dental extraction protocol with plasma rich in growth factors (PRGF) inserted into the postextraction alveolus vs Standard dental extraction protocol without PRGF

MRONJ (incidence proportion) · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)

It is very uncertain whether dental extraction protocol with plasma rich in growth factors (PRGF)… changes MRONJ (incidence proportion) compared with standard dental extraction protocol without PRGF (very low certainty).

1 finding from 1 review

Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
24 to 60 months
RR 0.08 [0.00, 1.51]
1 study · 176 participants
Very low

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence rate: cases per patient-year) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence rate: cases per patient-year) compared with standard care (very low certainty).

1 finding from 1 review

Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
mean 28.8 months
rate ratio 0.18 [0.04, 0.74]
1 study · 253 participants
Very low