Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 157 findings · 22 reviews · Heart

No studies found 6 · 3.8%GRADE not reported 7 · 4.5%Very low 23 · 14.6%Low 60 · 38.2%Moderate 44 · 28%High 17 · 10.8%

Self‐monitoring of oral anticoagulation vs usual care

Minor haemorrhage · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

Self‐monitoring of oral anticoagulation showed no clear difference in minor haemorrhage compared with standard care (moderate certainty).

1 finding from 1 review

self‐management of oral anticoagulation vs usual care

Thromboembolic events · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

self‐management of oral anticoagulation probably leads to lower thromboembolic events compared with standard care (moderate certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

The intervention showed no clear difference in all‐cause mortality Median (low certainty).

1 finding from 1 review

Intervention not reported

ASCVD event, such as fatal or non‐fatal myocardial infarction or stroke. Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

The intervention showed no clear difference in ASCVD event, such as fatal or non‐fatal myocardial infarction or… (low certainty).

1 finding from 1 review

Intervention not reported

Any investigator‐defined adverse event Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

The intervention probably leads to higher any investigator‐defined adverse event Median (moderate certainty).

1 finding from 1 review

Intervention not reported

Adherence, variable definitions Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

The intervention probably leads to higher adherence, variable definitions Median (moderate certainty).

1 finding from 1 review

Oxygen vs air

All‐cause mortality in hospital for participants with AMI · patients with acute myocardial infarction

It is very uncertain whether oxygen changes all‐cause mortality in hospital for participants with AMI compared with air (very low certainty).

1 finding from 1 review

Oxygen vs air

All‐cause mortality in hospital for all participants (including those without confirmed AMI) · patients with acute myocardial infarction

It is very uncertain whether oxygen changes all‐cause mortality in hospital for all participants (including… compared with air (very low certainty).

1 finding from 1 review

Oxygen vs air

All‐cause mortality in hospital for all participants (including those without confirmed AMI) trials done in the revascularisation era · patients with acute myocardial infarction

Oxygen showed no clear difference in all‐cause mortality in hospital for all participants (including… compared with air (low certainty).

1 finding from 1 review

Oxygen vs air

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · patients with acute myocardial infarction

Oxygen showed no clear difference in opiate use (as a proxy measure for pain) for all participants on ITT… compared with air (low certainty).

1 finding from 1 review

Oxygen vs air

Recurrent myocardial infarction (or ischaemia) · patients with acute myocardial infarction

Oxygen showed no clear difference in recurrent myocardial infarction (or ischaemia) compared with air (low certainty).

1 finding from 1 review

Intervention not reported

Mortality (all cause) Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention may leads to lower mortality (all cause) Long‐term (low certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal myocardial infarction Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention may leads to lower non‐fatal myocardial infarction Long‐term (low certainty).

1 finding from 1 review

Intervention not reported

Rehospitalisation due to heart failure Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention showed no clear difference in rehospitalisation due to heart failure Long‐term (low certainty).

1 finding from 1 review