What do systematic reviews say?

Children: formoterol/fluticasone vs regular salmeterol and fluticasone

Children: formoterol/fluticasone showed no clear difference in all‐cause non‐fatal serious adverse events compared with salmeterol/fluticasone (low certainty).

• Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
  OR 2.72 [0.38, 19.46]
  2 studies · 548 participants
  Low

Children: formoterol/fluticasone vs regular salmeterol and fluticasone

• Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 548 participants
  GRADE not reported

Regular formoterol vs regular salmeterol

• Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1116 participants
  Low

Regular formoterol vs regular salmeterol

• Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 156 participants
  Very low

Regular formoterol vs regular salmeterol

Regular formoterol showed no clear difference in all‐cause SAEs in adults compared with regular salmeterol (low certainty).

• Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
  OR 0.77 [0.46, 1.28]
  3 studies · 1116 participants
  Low

Regular formoterol vs regular salmeterol

It is very uncertain whether regular formoterol changes all‐cause SAEs in children compared with regular salmeterol (very low certainty).

• Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
  OR 0.95 [0.06, 15.33]
  1 study · 156 participants
  Very low

Regular formoterol vs regular salmeterol

Regular formoterol showed no clear difference in asthma‐related SAEs in adults compared with regular salmeterol (low certainty).

• Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
  OR 0.86 [0.29, 2.57]
  3 studies · 1116 participants
  Low

Regular formoterol vs regular salmeterol

• Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 156 participants
  Very low

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs beclomethasone

Effects of different inhaled corticosteroids on growth in children… may leads to higher linear growth velocity (cm/year) compared with beclomethasone (low certainty).

• Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth 2019 · Cochrane Headline outcomes only
  MD 0.81 [0.46, 1.16]
  1 study · 23 participants
  Low

Adults: prednisolone vs dexamethasone

It is very uncertain whether adults: prednisolone changes new exacerbation during compared with dexamethasone (very low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 1.32 [0.39, 4.47]
  1 study · 200 participants
  Very low
• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 1.85 [0.43, 7.96]
  1 study · 200 participants
  Very low

Children: prednisolone vs dexamethasone

Children: prednisolone showed no clear difference in admission at initial presentation compared with dexamethasone (low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 1.08 [0.74, 1.58]
  3 studies · 1007 participants
  Low

Children: prednisolone vs dexamethasone

Children: prednisolone showed no clear difference in re‐admission during compared with dexamethasone (low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.44 [0.15, 1.33]
  3 studies · 985 participants
  Low

Children: prednisolone vs dexamethasone

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 328 participants
  Very low
• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 533 participants
  GRADE not reported

Children: prednisolone vs dexamethasone

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 255 participants
  GRADE not reported

Children: prednisolone vs dexamethasone

Children: prednisolone showed no clear difference in new exacerbation during compared with dexamethasone (low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.85 [0.54, 1.34]
  4 studies · 981 participants
  Low

Adults: prednisolone vs dexamethasone

It is very uncertain whether adults: prednisolone changes re‐admission during compared with dexamethasone (very low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.35 [0.04, 3.47]
  1 study · 200 participants
  Very low

Adults: prednisolone vs dexamethasone

Adults: prednisolone showed no clear difference in asthma symptoms Returned to normal activities within 3 days compared with dexamethasone (low certainty).

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  OR 0.44 [0.19, 1.01]
  1 study · 191 participants
  Low

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  17 studies · 22819 participants
  GRADE not reported

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  Low

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 679 participants
  Low