Bridge failure · Adults (18 years or older) needing a three-unit tooth-supported fixed dental prosthesis
1 finding from 1 review
Plaque · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
Metal-free cantilevered FDPs (feldspathic-veneered zirconia) showed no clear difference in plaque index (PI) compared with metal-ceramic cantilevered FDPs; GRADE not reported.
1 finding from 1 review
Cantilevered bridge failure · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
1 finding from 1 review
Gingival index (GI) · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
Metal-free cantilevered FDPs (feldspathic-veneered zirconia) showed no clear difference in gingival index (GI) compared with metal-ceramic cantilevered FDPs; GRADE not reported.
1 finding from 1 review
Cantilevered bridge complications · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
It is very uncertain whether metal-free cantilevered FDPs (feldspathic-veneered zirconia) changes cantilevered bridge complications compared with metal-ceramic cantilevered FDPs (very low certainty).
1 finding from 1 review
All‐cause mortality, 30 days1 · patients of any age with AAA less than 30 mm in diameter
Metoprolol showed no clear difference in all‐cause mortality, 30 days1 compared with placebo (low certainty).
1 finding from 1 review
All cardiovascular death · patients of any age with AAA less than 30 mm in diameter
Metoprolol showed no clear difference in cardiovascular death, 30 days3 compared with placebo (low certainty).
2 findings from 1 review
AAA‐related death, 30 days4 · patients of any age with AAA less than 30 mm in diameter
Metoprolol showed no clear difference in AAA‐related death, 30 days4 compared with placebo (low certainty).
2 findings from 1 review
Nonfatal cardiovascular event, 30 days5 · patients of any age with AAA less than 30 mm in diameter
Metoprolol showed no clear difference in nonfatal cardiovascular event, 30 days5 compared with placebo (low certainty).
1 finding from 1 review
All‐cause mortality, 6 months1 · patients of any age with AAA less than 30 mm in diameter
Metoprolol showed no clear difference in all‐cause mortality, 6 months1 compared with placebo (low certainty).
1 finding from 1 review
Non‐fatal cardiovascular events · patients of any age with AAA less than 30 mm in diameter
Metoprolol showed no clear difference in nonfatal cardiovascular event, 6 months5 compared with placebo (low certainty).
1 finding from 1 review
All‐cause mortality
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
M + GLP1‐A
2 findings from 1 review
M + DPP4‐I
It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + DPP4‐I compared with metformin plus another antidiabetic drug (very low certainty).
3 findings from 1 review
RR 2.21 [0.74, 6.58]
4 studies · 5093 participants
Very low
no estimate extracted
1 study · 64 participants
Very low
RR 1.32 [0.76, 2.28]
9 studies · 11694 participants
Low
M + thiazolidinedione
It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + thiazolidinedione compared with metformin plus another antidiabetic drug (very low certainty).
2 findings from 1 review
M + nateglinide
4 findings from 1 review
no estimate extracted
1 study · 233 participants
Very low
no estimate extracted
3 studies · 874 participants
Low
no estimate extracted
2 studies · 446 participants
Low
Show 1 more finding
M + SGLT2‐I
It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + SGLT2‐I compared with metformin plus another antidiabetic drug (very low certainty).
2 findings from 1 review
Health‐related quality of life
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Non‐fatal stroke
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hysterectomy rate · endometrial hyperplasia
It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes hysterectomy rate compared with levonorgestrel intrauterine system (very low certainty).
1 finding from 1 review