Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

148 questions · 156 findings · 6 reviews · Anaesthesia

No studies found 44 · 28.2%GRADE not reported 18 · 11.5%Very low 32 · 20.5%Low 36 · 23.1%Moderate 19 · 12.2%High 7 · 4.5%

2% mepivacaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

2 findings from 1 review

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: paraesthesia following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

1 finding from 1 review
  • SoF: See comment; 0 participants (0 studies); 1 case of prolonged anaesthesia recorded; no clinical studies met the outcome definition (unable to confirm whether prolonged anaesthesia = paraesthesia).
    0 studies
    No studies found

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine showed no clear difference in adverse effects: pain on injection (solution deposition),… compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine probably leads to higher adverse effects: pain following injection, Heft-Parker VAS 0-170 mm compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review

Peribulbar vs retrobulbar

Local complications ‐ Conjunctival chemosis presence of conjunctival chemosis · patients undergoing cataract surgery

Peribulbar probably leads to higher local complications ‐ Conjunctival chemosis presence of conjunctival… compared with retrobulbar (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS –lidocaine vs bupivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS –lidocaine vs bupivacaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs 2‐chloroprocaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine showed no clear difference in presence of any TNS – lidocaine vs 2‐chloroprocaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs levobupivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine may leads to lower presence of any TNS – lidocaine vs levobupivacaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs mepivacaine · adults undergoing surgery

It is very uncertain whether risk of transient neurological symptoms with spinal lidocaine changes presence of any TNS – lidocaine vs mepivacaine compared with other local anaesthetic (very low certainty).

1 finding from 1 review

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs prilocaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine probably leads to lower presence of any TNS – lidocaine vs prilocaine compared with other local anaesthetic (moderate certainty).

1 finding from 1 review