Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

246 questions · 246 findings · 22 reviews · Metabolic and Endocrine Disorders

No studies found 106 · 43.1%GRADE not reported 5 · 2%Very low 49 · 19.9%Low 57 · 23.2%Moderate 26 · 10.6%High 3 · 1.2%

Summary of findings: pioglitazone monotherapy vs no intervention

All‐cause mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings: pioglitazone monotherapy changes all‐cause mortality (N) compared with no intervention (very low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs no intervention

Incidence of T2DM (N) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy probably leads to lower incidence of T2DM (N) Diagnostic criteria: 9 studies applied the WHO… compared with no intervention (moderate certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs no intervention

Serious adverse events (N) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy showed no clear difference in serious adverse events (N) compared with no intervention (low certainty).

1 finding from 1 review

Acarbose vs no intervention

(1) Non‐fatal myocardial infarction (2) Non‐fatal stroke (3) Congestive heart failure · people at increased risk for developing type 2 diabetes

It is very uncertain whether acarbose changes (a)Non‐fatal myocardial infarction (b)Non‐fatal stroke (c)Congestive… compared with no intervention (very low certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer occurrence · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D showed no clear difference in cancer occurrence compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer occurrence in trials using vitamin D₃ (cholecalciferol) · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D showed no clear difference in cancer occurrence in trials using vitamin D₃ (cholecalciferol) compared with placebo or no intervention (moderate certainty).

1 finding from 1 review