Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

336 questions · 427 findings · 28 reviews · Dental caries

No studies found 48 · 11.2%GRADE not reported 284 · 66.5%Very low 46 · 10.8%Low 25 · 5.9%Moderate 24 · 5.6%High 0 · 0%

High-dose vitamin D3 supplementation during pregnancy (2400 IU/day from pregnancy week 24 to 1 week postpartum, in addition to the recommended 400 IU/day) vs Low-dose (standard) vitamin D supplementation as recommended in national pregnancy guidelines

Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

The review found no eligible studies for this question.

2 findings from 1 review

Package of oral health education/promotion including oral hygiene advice for pregnant women, mothers, infants and young children, plus dietary and feeding practice advice for infants and young children vs usual care

Child microbiological presence (any mutans streptococci colonisation) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

Package of oral health education/promotion including oral hygiene… showed no clear difference in child microbiological presence (mutans streptococci colonisation) compared with standard care; GRADE not reported.

1 finding from 1 review

Package of oral health education/promotion including oral hygiene advice for pregnant women, mothers, infants and young children, plus dietary and feeding practice advice for infants and young children vs usual care

SiC30 index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

Package of oral health education/promotion including oral hygiene… led to lower siC30 index score compared with standard care; GRADE not reported.

1 finding from 1 review

Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in the dentition of women (mothers) vs placebo

Mother caries (dmfs increment) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution… showed no clear difference in mother caries (dmfs increment) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral health education only (verbal, written, or audio-visual education) delivered by non-dental health workers vs control (no intervention/usual care/isotonic exercise)

Caries experience · Children (mean age newborn to ~5.2 years) and their parents/carers

Oral-health-education-only interventions showed at most a marginal effect on tooth-level caries (dmft SMD -0.11, 95% CI -0.21 to -0.00; 2 studies; not GRADE-rated).

1 finding from 1 review

Oral health education only (verbal, written, or audio-visual education) delivered by non-dental health workers vs control (no intervention/usual care/isotonic exercise)

Caries experience at the surface level (dmfs/defs) · Children (mean age newborn to ~5.2 years) and their parents/carers

Oral-health-education-only interventions did not show a statistically significant effect on surface-level caries (dmfs SMD -0.20, 95% CI -0.43 to 0.03; 2 studies; not GRADE-rated).

1 finding from 1 review

Community and caregiver oral health education plus media campaign vs Pre-intervention BBTD rate

Baby bottle tooth decay prevalence · Alaska Native and American Indian Head Start children

High-intensity community education was associated with a 33% reduction in BBTD prevalence, without a GRADE rating.

3 findings from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected Significant Caries (SiC) index · Alaska Native children (below age 18)

A simulation projected a 50% drop in the Significant Caries index for children (12.3 to 6.1) under the PDHA model (certainty not graded).

2 findings from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected proportion of caries-free children (5-18 years) · Alaska Native children (below age 18)

A simulation projected 0% of children aged 5-18 would be caries-free under the baseline scenario (certainty not graded).

3 findings from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected receipt of school-based prevention services · Alaska Native children (below age 18)

A simulation projected that over 90% of children would receive school-based prevention services under the PDHA model, up from 53% (certainty not graded).

1 finding from 1 review

Community and caregiver oral health education plus media campaign vs Pre-intervention baseline (and sites that discontinued the prevention program)

Reduction in prevalence of baby bottle tooth decay (BBTD) · Alaska Native and American Indian Head Start children

Community and caregiver oral health education was associated with a significant ~25% overall reduction in baby bottle tooth decay among Head Start children (certainty not graded).

1 finding from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected dental care utilisation · Alaska Native children (below age 18)

A simulation projected that the PDHA program would raise dental care utilisation from 75% to 90% (certainty not graded).

1 finding from 1 review

Community and caregiver oral health education plus media campaign vs Pre-intervention BBTD rate

Baby bottle tooth decay prevalence · Alaska Native Head Start children

The Alaska Native site had a 20% increase in BBTD prevalence, without a GRADE rating.

1 finding from 1 review

PDHA program vs Baseline pre-intervention service-delivery scenario

School-based oral health promotion services · Alaska children

The PDHA program was projected to raise school-based oral health promotion service receipt from 53% to more than 90%, without a GRADE rating.

1 finding from 1 review

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected mean DMFT (children below 5 years) · Alaska Native children (below age 18)

A simulation projected mean DMFT in children under 5 would fall from 7.4 to 4.9 under the PDHA model (certainty not graded).

1 finding from 1 review