Microbiology Emergence of resistant organisms · adults and children with cystic fibrosis (during acute exacerbations of lung disease)
It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes microbiology Emergence of resistant organisms compared with IV antibiotics only (very low certainty).
1 finding from 1 review
Quality of life: number of participants achieving MCID · adults and children with cystic fibrosis (during acute exacerbations of lung disease)
Summary of findings: Inhaled antibiotics plus IV antibiotics showed no clear difference in quality of life: number of participants achieving MCID compared with IV antibiotics only (low certainty).
1 finding from 1 review
Time off school or work · adults and children with cystic fibrosis (during acute exacerbations of lung disease)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Eradication of P aeruginosa from the respiratory tract: proportion with positive respiratory culture for P aeruginosa · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
Inhaled tobramycin (TNS) may leads to lower eradication of P aeruginosa from the respiratory tract: proportion… compared with placebo (low certainty).
1 finding from 1 review
FEV1 · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review
FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review
Change in weight (kg) · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects of antibiotics: participants experiencing cough · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
It is very uncertain whether inhaled tobramycin (TNS) changes adverse effects of antibiotics: participants experiencing cough compared with placebo (very low certainty).
1 finding from 1 review
Adherence to inhaled therapies cMPR · children aged 5 to 16 years
Digital technology (TIM) may leads to higher adherence to the inhaled treatment: compared with standard treatment (TBM) (low certainty).
1 finding from 1 review
Adherence to the inhaled treatment: percentage adherence · adults (aged 16 years and over) with CF
Digital technology (web‐based platform CFHealthHub) probably leads to higher adherence to the inhaled treatment: percentage adherence compared with usual care (moderate certainty).
1 finding from 1 review
Adherence to inhaled therapies cMPR · children, adolescents or adults with CF
Summary of findings: psychological interventions probably leads to higher adherence to inhaled therapies: % of prescribed inhaled therapies… compared with usual care (moderate certainty).
1 finding from 1 review
Adherence to inhaled therapies cMPR · adults (aged 16 years and over) with CF
1 finding from 1 review
Eradication of P aeruginosa from the respiratory tract: proportion of participants with one or more isolates of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
FEV1 (% predicted): mean change from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review
FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Growth and nutritional status · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review
Pulmonary exacerbations · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
Cycled inhaled tobramycin (TNS) probably leads to lower frequency of infective pulmonary exacerbations: proportion of… compared with culture‐based TNS (moderate certainty).
1 finding from 1 review
Isolation of other micro‐organisms from the respiratory tract: proportion of participants with new isolates of Stenotrophomonas maltophilia · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
Cycled inhaled tobramycin (TNS) showed no clear difference in isolation of other micro‐organisms from the respiratory tract:… compared with culture‐based TNS (moderate certainty).
1 finding from 1 review