Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

130 questions · 137 findings · 36 reviews · Musculoskeletal

No studies found 6 · 4.4%GRADE not reported 3 · 2.2%Very low 18 · 13.1%Low 55 · 40.1%Moderate 41 · 29.9%High 14 · 10.2%

Intervention not reported

Function: change from baseline WOMAC VAS (Function; higher means worse) · patients with osteoarthritis of the knee
1 finding from 1 review

Intervention not reported

Pain VAS 0‐100 (higher means worse) · patients with osteoarthritis of the knee
1 finding from 1 review

Intervention not reported

Function WOMAC 0‐4 (Function; higher means worse) · patients with osteoarthritis of the knee
1 finding from 1 review

Intervention not reported

Function WOMAC 0‐4 (Overall; higher means worse) · patients with osteoarthritis of the knee
1 finding from 1 review

Intervention not reported

Pain (short term) WOMAC scale from 0 to 20 points (higher is worse pain). · Patients with peripheral joint osteoarthritis
1 finding from 1 review

Intervention not reported

Function (long term) WOMAC scale from 0 to 68 points (higher is worse function). · Patients with knee osteoarthritis
1 finding from 1 review

Intervention not reported

Function (short term) WOMAC scale from 0 to 68 points (higher is worse function). · Patients with peripheral joint osteoarthritis
1 finding from 1 review

Intervention not reported

Pain (long term) WOMAC scale from 0 to 20 points (higher is worse pain). · Patients with peripheral joint osteoarthritis
1 finding from 1 review

Intervention not reported

Function (long term) WOMAC scale from 0 to 68 points (higher is worse function). · Patients with peripheral joint osteoarthritis
1 finding from 1 review

Intervention not reported

Pain (short term) WOMAC scale from 0 to 20 points (higher is worse pain). · Patients with knee osteoarthritis
1 finding from 1 review

Intervention not reported

Function (short term) WOMAC scale from 0 to 68 points (higher is worse function). · Patients with knee osteoarthritis
1 finding from 1 review

Intervention not reported

Pain (long term) WOMAC scale from 0 to 20 points (higher is worse pain). · Patients with knee osteoarthritis
1 finding from 1 review

Intermittent/cyclic etidronate 400 mg/day vs placebo

Withdrawals due to adverse events · postmenopausal women with a higher risk for fracturesa

It is very uncertain whether intermittent/cyclic etidronate 400 mg/day changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review