What do systematic reviews say?

Chemotherapy with TKI (peptide‐Fc fusion protein) vs chemotherapy alone

Chemotherapy with TKI (peptide‐Fc fusion protein) showed no clear difference in overall survival (OS) compared with chemotherapy alone (moderate certainty).

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  HR 0.92 [0.8, 1.06]
  3 studies · 1250 participants
  Moderate

Chemotherapy with TKI (peptide‐Fc fusion protein) vs chemotherapy alone

Chemotherapy with TKI (peptide‐Fc fusion protein) leads to lower progression‐free survival (PFS) compared with chemotherapy alone (high certainty).

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  HR 0.73 [0.65, 0.82]
  3 studies · 1250 participants
  High

Chemotherapy with TKI (peptide‐Fc fusion protein) vs chemotherapy alone

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 315 participants
  Low

Chemotherapy with TKI (peptide‐Fc fusion protein) vs chemotherapy alone

The review found no eligible studies for this question.

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Chemotherapy with TKI (peptide‐Fc fusion protein) vs chemotherapy alone

The review found no eligible studies for this question.

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Chemotherapy with TKI (peptide‐Fc fusion protein) vs chemotherapy alone

Chemotherapy with TKI (peptide‐Fc fusion protein) showed no clear difference in bowel fistula / perforation (grade ≥ 3) compared with chemotherapy alone (low certainty).

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  RR 0.35 [0.01, 8.3]
  1 study · 108 participants
  Low

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Chemotherapy with TKI followed by TKI maintenance showed no clear difference in overall survival (OS) compared with chemotherapy alone (moderate certainty).

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  HR 0.99 [0.84, 1.17]
  2 studies · 1451 participants
  Moderate

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Chemotherapy with TKI followed by TKI maintenance showed no clear difference in progression‐free survival (PSF) compared with chemotherapy alone (moderate certainty).

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  HR 0.88 [0.77, 1]
  2 studies · 1451 participants
  Moderate

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1340 participants
  Moderate

Third generation cephalosporins vs conventional therapy

• Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
  no estimate extracted
  19 studies · 1496 participants
  GRADE not reported

Third generation cephalosporins vs conventional therapy

• Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
  no estimate extracted
  13 studies · 477 participants
  GRADE not reported

Third generation cephalosporins vs conventional therapy

• Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 501 participants
  GRADE not reported

Third generation cephalosporins vs conventional therapy

• Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 442 participants
  GRADE not reported

Third generation cephalosporins vs conventional therapy

• Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 750 participants
  GRADE not reported

Third generation cephalosporins vs conventional therapy

• Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 472 participants
  GRADE not reported

Third generation cephalosporins vs conventional therapy

• Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 533 participants
  GRADE not reported

Third generation cephalosporins vs conventional therapy

• Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis 2007 · Cochrane Headline outcomes only
  no estimate extracted
  19 studies · 1496 participants
  GRADE not reported

Chemotherapy with bevacizumab followed by bevacizumab maintenance vs chemotherapy alone

Chemotherapy with bevacizumab followed by maintenance bevacizumab showed no clear difference in overall survival (OS) compared with chemotherapy alone (moderate certainty).

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  HR 0.97 [0.88, 1.07]
  2 studies · 2776 participants
  Moderate

Chemotherapy with bevacizumab followed by bevacizumab maintenance vs chemotherapy alone

Chemotherapy with bevacizumab followed by bevacizumab maintenance showed no clear difference in overall survival (OS) compared with chemotherapy alone (moderate certainty).

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  HR 0.9 [0.79, 1.02]
  3 studies · 1564 participants
  Moderate

Chemotherapy with bevacizumab followed by bevacizumab maintenance vs chemotherapy alone

It is very uncertain whether chemotherapy with bevacizumab followed by maintenance bevacizumab changes progression‐free survival (PFS) compared with chemotherapy alone (very low certainty).

• Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
  HR 0.82 [0.64, 1.05]
  2 studies · 2746 participants
  Very low