Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

118 questions · 118 findings · 14 reviews

No studies found 13 · 11%GRADE not reported 1 · 0.8%Very low 67 · 56.8%Low 32 · 27.1%Moderate 5 · 4.2%High 0 · 0%

PUFA vs placebo

50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐ Older (19 years or more) · patients with drug‐resistant epilepsy

PUFA showed no clear difference in 50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐… compared with placebo (low certainty).

1 finding from 1 review

PUFA vs placebo

50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐ Younger (< 19 years) · patients with drug‐resistant epilepsy

PUFA may leads to higher 50% reduction in seizures frequency (12 weeks) ‐ Per protocol data ‐… compared with placebo (low certainty).

1 finding from 1 review