Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls
The pooled odds ratio was 1.63 (95% CI 0.67 to 4.01).
1 finding from 1 review
OR 1.63 [0.67, 4.01]
2 studies
GRADE not reported
Dental erosion · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)
Reflux (GERD/LPR) is associated with a higher prevalence and severity of dental erosion than in healthy individuals, but the evidence is heterogeneous, not pooled, and ungraded.
1 finding from 1 review
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between AG genotype vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG vs AA model: OR 1.21, 95% CI 0.88-1.65); certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC genotype of AMELX rs6639060 and dental caries susceptibility (TT vs CC model: OR 1.04, 95% CI 0.43-2.51) in the Age group: Adults subgroup; certainty not graded.
3 findings from 1 review
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between CT genotype vs CC genotype of AMELX rs946252 and dental caries susceptibility (CT vs CC model: OR 2.80, 95% CI 0.93-8.43) in the Ethnicity: Caucasian subgroup; certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between GG genotype vs AA + AG genotype of LTF rs1126478 and dental caries susceptibility (GG vs AA + AG model: OR 0.95, 95% CI 0.80-1.13) in the Age group: Children subgroup; certainty not graded.
5 findings from 1 review
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Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls
The pooled odds ratio was 0.98 (95% CI 0.87 to 1.10).
1 finding from 1 review
OR 0.98 [0.87, 1.10]
4 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
The CT genotype of AMELX rs17878486 was associated with increased dental caries risk (CT vs CC model: OR 5.11, 95% CI 1.33-19.72) in the Ethnicity: Mixed subgroup; certainty not graded.
9 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between GG genotype vs AA + AG genotype of ENAM rs3796704 and dental caries susceptibility (GG vs AA + AG model: OR 1.05, 95% CI 0.66-1.68) in the Control group: Low caries subgroup; certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls
The pooled odds ratio was 0.95 (95% CI 0.35 to 2.55).
1 finding from 1 review
OR 0.95 [0.35, 2.55]
2 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs946252 and dental caries susceptibility (CT + TT vs CC model: OR 1.63, 95% CI 0.67-4.01) in the Ethnicity: Caucasian subgroup; certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between T allele vs C allele of AMELX rs946252 and dental caries susceptibility (T vs C model: OR 0.99, 95% CI 0.53-1.86) in the Ethnicity: Mixed subgroup; certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between G allele vs A allele of ENAM rs3796704 and dental caries susceptibility (G vs A model: OR 1.11, 95% CI 0.57-2.15) in the Ethnicity: Mixed subgroup; certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between G allele vs A allele of ENAM rs1264848 and dental caries susceptibility (G vs A model: OR 0.93, 95% CI 0.65-1.32); certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between AG genotype vs AA genotype of ENAM rs3796704 and dental caries susceptibility (AG vs AA model: OR 0.35, 95% CI 0.07-1.74) in the Age group: Children subgroup; certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
The CT + TT genotype (T-allele carriers) of AMELX rs17878486 was associated with increased dental caries risk (CT + TT vs CC model: OR 5.72, 95% CI 2.83-11.59) after excluding the outlier study (Ergoz 2014); certainty not graded.
9 findings from 1 review
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Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomesCase-control genetic association studies (multiple countries) · Control group: Low caries
OR 3.43 [1.21, 9.75]
2 studies
GRADE not reported
OR 0.89 [0.04, 22.53]
1 study
GRADE not reported
OR 4.03 [1.27, 12.75]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomesCase-control genetic association studies (multiple countries) · Age group: Children
OR 2.65 [0.49, 14.35]
3 studies
GRADE not reported
OR 0.89 [0.04, 22.53]
1 study
GRADE not reported
Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomesCase-control genetic association studies (multiple countries) · Ethnicity: Caucasian
OR 2.03 [0.10, 42.44]
2 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between AG genotype vs AA genotype of LTF rs1126478 and dental caries susceptibility (AG vs AA model: OR 1.07, 95% CI 0.80-1.43) in the Ethnicity: Asian subgroup; certainty not graded.
5 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs6639060 and dental caries susceptibility (CT + TT vs CC model: OR 1.14, 95% CI 0.56-2.29) in the Ethnicity: Caucasian subgroup; certainty not graded.
3 findings from 1 review
Dental caries susceptibility · Ethnicity: Caucasian (n=1) individuals with caries/high caries and controls
The pooled odds ratio was 1.04 (95% CI 0.43 to 2.51).
1 finding from 1 review
OR 1.04 [0.43, 2.51]
1 study
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC genotype of AMELX rs946252 and dental caries susceptibility (TT vs CC model: OR 1.54, 95% CI 0.61-3.92) in the Age group: Children subgroup; certainty not graded.
6 findings from 1 review
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