What do systematic reviews say?

Canakinumab vs placebo

• Interventions for reducing inflammation in familial Mediterranean fever 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 63 participants
  Moderate

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) vs Colchicine (systemic; 1 mg daily)

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
  Masuda 1989: multiple adverse events in the cyclosporin arm; 3 patients withdrew and 9 had a dose reduction as a result.
  1 study · 92 participants
  GRADE not reported

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) vs Colchicine (systemic; 1 mg daily)

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) led to higher alleviation of oral aphthous ulcers compared with colchicine (systemic; 1 mg daily); GRADE not reported.

• Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes

  16 weeks
  RR 3.3 [1.85, 5.88]
  1 study · 92 participants
  GRADE not reported

Intervention not reported

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 0.41 [0.28, 0.61]
  2 studies · 360 participants
  Moderate

Intervention not reported

The intervention may leads to higher symptom relief at 72 hours Patient reported (low certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 1.4 [1.26, 1.56]
  4 studies · 564 participants
  Low

Intervention not reported

The intervention showed no clear difference in total adverse effects Patient reported (low certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 1.26 [0.75, 2.12]
  4 studies · 564 participants
  Low

Intervention not reported

The intervention probably leads to higher adverse effects necessitating stop of therapy Patient reported (moderate certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 1.87 [1.02, 3.41]
  4 studies · 564 participants
  Moderate

Intervention not reported

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 0.28 [0.17, 0.47]
  2 studies · 204 participants
  Moderate

Intervention not reported

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 0.36 [0.23, 0.56]
  2 studies · 204 participants
  Moderate

Intervention not reported

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 0.38 [0.25, 0.58]
  2 studies · 204 participants
  Moderate

Intervention not reported

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 0.36 [0.23, 0.58]
  2 studies · 360 participants
  Moderate

Intervention not reported

The intervention probably leads to lower months Chest pain + (ECG changes +/‐ echocardiographic changes +/‐… (moderate certainty).

• Colchicine for pericarditis 2014 · Cochrane Headline outcomes only
  RR 0.4 [0.26, 0.61]
  2 studies · 360 participants
  Moderate