What do systematic reviews say?

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low

Rupatadine 10 to 20 mg vs placebo

Rupatadine 10 to 20 mg may leads to higher good or excellent response Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.35 [1.03, 1.77]
  1 study · 245 participants
  Low

Loratadine 10 mg vs placebo

Loratadine 10 mg showed no clear difference in good or excellent response Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.86 [0.91, 3.79]
  2 studies · 124 participants
  Low

Loratadine 10 mg vs cetirizine (antihistamine)

Loratadine 10 mg showed no clear difference in complete cessation of urticaria Global assessment of symptom scores compared with cetirizine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.05 [0.76, 1.43]
  2 studies · 103 participants
  Low

Loratadine 10 mg vs desloratadine 5 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.64, 1.71]
  3 studies · 410 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

It is very uncertain whether loratadine 10 mg changes complete cessation of urticaria: intermediate‐term duration of… compared with mizolastine 10 mg (very low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.86 [0.64, 1.16]
  3 studies · 316 participants
  Very low

Loratadine 10 mg vs mizolastine 10 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with mizolastine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.88 [0.55, 1.42]
  3 studies · 314 participants
  Low

Loratadine 10 mg vs emedastine 2 mg

Loratadine 10 mg showed no clear difference in complete cessation of urticaria: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.78, 1.39]
  1 study · 161 participants
  Moderate

Loratadine 10 mg vs emedastine 2 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.09 [0.96, 1.24]
  1 study · 160 participants
  Moderate

Loratadine 10 mg vs hydroxyzine 25 mg

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: short‐term duration of… compared with hydroxyzine 25 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1 [0.32, 3.1]
  1 study · 12 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Calcineurin inhibitor vs steroids

Calcineurin inhibitor showed no clear difference in total clearance (at 4 weeks or less) Investigator's assessment compared with steroid (low certainty).

• Topical anti‐inflammatory agents for seborrhoeic dermatitis of the face or scalp 2014 · Cochrane Headline outcomes only
  RR 1.08 [0.88, 1.32]
  2 studies · 60 participants
  Low

Steroids vs azole

Steroid showed no clear difference in total clearance (at 4 weeks or less) Investigator's assessment compared with azole (moderate certainty).

• Topical anti‐inflammatory agents for seborrhoeic dermatitis of the face or scalp 2014 · Cochrane Headline outcomes only
  RR 1.11 [0.94, 1.32]
  8 studies · 464 participants
  Moderate

Strong steroid (class III or IV) vs mild steroid (class I or II)

Strong steroid (class III or IV) showed no clear difference in total clearance (at 4 weeks or less) Investigator's assessment compared with mild steroid (class I or II) (moderate certainty).

• Topical anti‐inflammatory agents for seborrhoeic dermatitis of the face or scalp 2014 · Cochrane Headline outcomes only
  RR 0.96 [0.65, 1.4]
  2 studies · 93 participants
  Moderate