Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

131 questions · 131 findings · 10 reviews

No studies found 22 · 16.8%GRADE not reported 9 · 6.9%Very low 22 · 16.8%Low 37 · 28.2%Moderate 29 · 22.1%High 12 · 9.2%

Intervention not reported

Any reported infant death (fetal, neonatal, or before hospital discharge · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower any reported infant death (fetal, neonatal, or before hospital… (high certainty).

1 finding from 1 review

Intervention not reported

Preterm birth (before 37 weeks' gestation) · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower preterm birth (before 37 weeks' gestation) (high certainty).

1 finding from 1 review

Intervention not reported

Small‐for‐gestational age · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower small‐for‐gestational age (high certainty).

1 finding from 1 review

Intervention not reported

Pregnancy with serious adverse outcome (composite including maternal death, baby death, pre‐eclampsia, small‐for‐gestational age, preterm birth) ‐ only trials with individual participant data · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention leads to lower pregnancy with serious adverse outcome (composite including maternal… (high certainty).

1 finding from 1 review

Intervention not reported

Postpartum haemorrhage > 500 mL · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention showed no clear difference in postpartum haemorrhage > 500 mL (moderate certainty).

1 finding from 1 review

Intervention not reported

Placental abruption · pregnant women considered to be at risk of developing pre‐eclampsia

The intervention showed no clear difference in placental abruption (moderate certainty).

1 finding from 1 review

ASA with LMWH vs placebo or IVIG

Bleeding ‐ major (bleeding requiring transfusion) Length of · people with antiphospholipid antibodies and no history of thrombosis

ASA with LMWH showed no clear difference in bleeding ‐ major (bleeding requiring transfusion) Length of compared with placebo or IVIG (moderate certainty).

1 finding from 1 review

ASA with LMWH vs placebo or IVIG

Bleeding ‐ other (bleeding during first trimester) Length of · people with antiphospholipid antibodies and no history of thrombosis

ASA with LMWH showed no clear difference in bleeding ‐ other (bleeding during first trimester) Length of compared with placebo or IVIG (moderate certainty).

1 finding from 1 review

ASA with LMWH vs placebo or IVIG

Bleeding ‐ other (postpartum haemorrhage) Length of · people with antiphospholipid antibodies and no history of thrombosis

ASA with LMWH showed no clear difference in bleeding ‐ other (postpartum haemorrhage) Length of compared with placebo or IVIG (moderate certainty).

1 finding from 1 review