Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 166 findings · 21 reviews

No studies found 10 · 6%GRADE not reported 19 · 11.4%Very low 32 · 19.3%Low 65 · 39.2%Moderate 34 · 20.5%High 6 · 3.6%

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Failure of acute rejection reversal · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) showed no clear difference in failure of acute rejection reversal compared with other antibody (stratified by comparator) (moderate certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Recurrent rejection · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) showed no clear difference in recurrent rejection compared with other antibody (stratified by comparator) (moderate certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Treatment adverse events: fever, chills, malaise after drug administration · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) may leads to higher treatment adverse events: fever, chills, malaise after drug… compared with other antibody (stratified by comparator) (low certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Neurological adverse effects · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) may leads to higher treatment adverse events: neurological side effects compared with other antibody (stratified by comparator) (low certainty).

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Overall survival (reported as mortality) · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

Dinutuximab‐containing immunotherapy probably leads to lower overall survival (reported as mortality) compared with standard therapy (moderate certainty).

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Treatment‐related mortality ‐ not reported · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Progression‐free survival ‐ not reported · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Event‐free survival · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

Dinutuximab‐containing immunotherapy probably leads to lower event‐free survival (reported as relapse, progressive disease,… compared with standard therapy (moderate certainty).

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Late non‐haematological toxicity ‐ not reported · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review

Dinutuximab‐containing immunotherapy vs usual care

Health‐related quality of life ‐ not reported · People with high‐risk neuroblastoma pre‐treated with autologous haematopoietic stem cell transplantation

The review found no eligible studies for this question.

1 finding from 1 review