Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

138 questions · 140 findings · 14 reviews · Kidney and Transplant

No studies found 22 · 15.7%GRADE not reported 0 · 0%Very low 46 · 32.9%Low 47 · 33.6%Moderate 25 · 17.9%High 0 · 0%

Probiotics vs antibiotic prophylaxis

Renal parenchymal defects on DMSA scan ‐ Patient data at 1 year · primary VUR

Probiotics showed no clear difference in renal parenchymal defects on DMSA scan ‐ Patient data at 1 year compared with antibiotic prophylaxis (low certainty).

1 finding from 1 review

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Peritonitis · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in peritonitis (number of patients with one or more episodes) compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Exit‐site/tunnel infection · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in exit‐site/tunnel infection (number of patients with one or more… compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Catheter removal or replacement · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in catheter removal or replacement (number of patients) compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review

Intervention not reported

Number of subjects who developed symptomatic UTI (6 months to 1 year) · adults with asymptomatic bacteriuria

The intervention showed no clear difference in number of subjects who developed symptomatic UTI (6 months to 1 year) (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of subjects who developed complications (10 months to 3 years) · adults with asymptomatic bacteriuria

The intervention showed no clear difference in number of subjects who developed complications (10 months to 3 years) (moderate certainty).

1 finding from 1 review

Intervention not reported

Death (6 months to 8 years) · adults with asymptomatic bacteriuria

The intervention showed no clear difference in death (6 months to 8 years) (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of subjects who develop any adverse event (42 days to 10 months) · adults with asymptomatic bacteriuria

The intervention probably leads to higher number of subjects who develop any adverse event (42 days to 10… (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of subjects with bacteriological cure (42 days to 4 years) · adults with asymptomatic bacteriuria

The intervention probably leads to higher number of subjects with bacteriological cure (42 days to 4 years) (moderate certainty).

1 finding from 1 review

Oral vs IV followed by oral (11 days) therapy

Renal parenchymal damage at 6 to 12 months: all included children with acute pyelonephritis DMSA scans · children with acute pyelonephritis

Oral showed no clear difference in renal parenchymal damage at 6 to 12 months: all included children… compared with IV followed by oral (11 days) therapy (moderate certainty).

1 finding from 1 review

Oral vs IV followed by oral (11 days) therapy

Renal parenchymal damage at 6 to 12 months: children with renal parenchymal damage on initial DMSA · children with acute pyelonephritis

Oral showed no clear difference in renal parenchymal damage at 6 to 12 months: children with renal… compared with IV followed by oral (11 days) therapy (moderate certainty).

1 finding from 1 review