Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

279 questions · 283 findings · 23 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 96 · 33.9%GRADE not reported 1 · 0.4%Very low 47 · 16.6%Low 62 · 21.9%Moderate 62 · 21.9%High 15 · 5.3%

Summary of findings: cycled vs culture‐based antibiotic therapy

Time to next isolation of PA · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled probably leads to higher time to next isolation of PA compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings: cycled vs culture‐based antibiotic therapy

Adverse events: severe adverse events (total) · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled showed no clear difference in adverse events: severe adverse events (total) compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings: cycled vs culture‐based antibiotic therapy

Emergence of novel bacteria: isolation of novel gram negative organisms · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled showed no clear difference in emergence of novel bacteria: isolation of novel gram negative… compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review