Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

203 questions · 206 findings · 21 reviews

No studies found 51 · 24.8%GRADE not reported 11 · 5.3%Very low 59 · 28.6%Low 57 · 27.7%Moderate 19 · 9.2%High 9 · 4.4%

Paracetamol vs ibuprofen

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm or low birth weight infants with PDA

Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with ibuprofen (moderate certainty).

1 finding from 1 review

Early paracetamol vs placebo or no intervention

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm or low birth weight infants with PDA

Early paracetamol may leads to lower failure of PDA closure after first course of treatment (by… compared with placebo/no intervention (low certainty).

1 finding from 1 review