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Evidence found and GRADE certainty

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

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No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Intervention not reported

Major bleeding ( · patients with less than 42 days' lower limb ischaemia

It is very uncertain whether the intervention changes major bleeding ( (very low certainty).

1 finding from 1 review

Higher threshold (500 mL per six hours or greater) vs lower threshold (less than 500 mL per six hours) at time of aspiration

Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether higher threshold (500 mL per six hours or greater) changes mortality (at the end of compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).

1 finding from 1 review

Higher threshold (500 mL per six hours or greater) vs lower threshold (less than 500 mL per six hours) at time of aspiration

Pneumonia · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether higher threshold (500 mL per six hours or greater) changes pneumonia (until discontinued or up to 28 days) compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).

1 finding from 1 review

Vitamin D (higher dose) vs vitamin D (lower dose)

Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age

Vitamin D (higher dose) showed no clear difference in adverse effect: hypercalciuria As defined by trialists Time frame:… compared with vitamin D (lower dose) (low certainty).

1 finding from 1 review

Vitamin D (higher dose) vs vitamin D (lower dose)

Hypercalcaemia · children under 5 years of age

Vitamin D (higher dose) showed no clear difference in adverse effect: hypercalcaemia As defined by trialists Time frame:… compared with vitamin D (lower dose) (low certainty).

1 finding from 1 review

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age

Vitamin D (higher dose) + micronutrient(s) showed no clear difference in adverse effect: hypercalciuria As defined by trialists Time frame: 3… compared with vitamin D (lower dose) + micronutrient(s) (low certainty).

1 finding from 1 review

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

Hypercalcaemia · children under 5 years of age

Vitamin D (higher dose) + micronutrient(s) showed no clear difference in adverse effect: hypercalcaemia As defined by trialists Time frame:… compared with vitamin D (lower dose) + micronutrient(s) (moderate certainty).

1 finding from 1 review