Organoleptic assessment of halitosis (mean change from baseline) · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
Borden 2002: mean change in organoleptic score (scale 0 to 5). Essential oils (Listerine): 0.02 at 2 weeks, 0 at 4 weeks; Placebo: 0.23 at 2 weeks, 0.16 at 4 weeks. Listerine did not reduce organoleptic scores. No…
1 study
GRADE not reported
Difficulty in drinking (number with drinking difficulties) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
Systemic oral acyclovir led to lower number of individuals with drinking difficulties (8 days after… compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Number of individuals admitted to hospital after administration · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
Systemic oral acyclovir showed no clear difference in number of individuals admitted to hospital after administration compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Volatile sulphur compounds (VSC), halimeter · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
Borden 2002: mean change in halimeter-assessed VSC (ppb). Essential oils (Listerine): -43.22 at 2 weeks (48.54% reduction), -68.90 at 4 weeks (77.39% reduction); Placebo: -39.86 at 2 weeks (45.25%), -36.77 at 4 weeks…
1 study
GRADE not reported
Organoleptic assessment (indirect surrogate salivary organoleptic score) · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
Duration of fever · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
Volatile sulphur compounds (VSC), halimeter · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
Patient or parental satisfaction (tolerance and acceptability of drug) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
Adverse effect: failure of muscle fusion in the region of the cleft after surgery · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate
1 finding from 1 review
Adverse effect: unacceptable nasal resonance after repair · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
Adverse effect: obstructive sleep apnoea or airway compromise · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate
1 finding from 1 review
Perceptual speech assessment: residual post-operative velopharyngeal insufficiency · Children or adolescents aged 3 years or older with velopharyngeal insufficiency (VPI) associated with non-syndromic submucous cleft palate
1 finding from 1 review
Five (14%) of the participants in group 1 (MIPP) and four (11%) in group 2 had residual post-operative velopharyngeal insufficiency, P > 0.05. The report provided no details on post-operative speech assessment other…
1 study · 72 participants
GRADE not reported
QoL · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
The review found no eligible studies for this question.
1 finding from 1 review
Mean time to resolution of pain · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
Amir 1997b: no data available. Ducoulombier 1988: time to resolution of pain, acyclovir (1 day=1, 2 days=1, 3 days=3, 4 days=3, 5 days=1, persistent=0) vs placebo (1 day=0, 2 days=0, 3 days=1, 4 days=2, 5 days=4,…
1 study · 18 participants
GRADE not reported
Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy
Antifungal drugs partially absorbed from GI tract (miconazole,… showed no clear difference in systemic fungal infection compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy
Antifungal drugs not absorbed from GI tract showed no clear difference in oral candidiasis (present) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy
Amphotericin B showed no clear difference in oral candidiasis (present) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Empirical antifungal treatment · Patients with cancer receiving chemotherapy and/or radiotherapy
Itraconazole showed no clear difference in empirical antifungal treatment compared with fluconazole; GRADE not reported.
1 finding from 1 review
Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy
Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole,… showed no clear difference in systemic fungal infection compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review