Findings

What do systematic reviews say?

1,520 questions · 1,575 findings · 175 reviews · Headline outcomes only

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No studies found 239 · 15.2%GRADE not reported 59 · 3.7%Very low 337 · 21.4%Low 406 · 25.8%Moderate 410 · 26%High 124 · 7.9%

Intravitreal fluocinolone acetonide implant 0.19 mg vs sham

Change in retinal thickness (micron) ‐ 12 months (negative is better) · macular edema in diabetes

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 560 participants
Moderate

Intravitreal fluocinolone acetonide implant 0.19 mg vs sham

Cataract progression ‐ 24 months · macular edema in diabetes

Intravitreal fluocinolone acetonide implant 0.19 mg probably leads to higher cataract progression ‐ 24 months compared with sham (moderate certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 1.63 [1.35, 1.97]
1 study · 355 participants
Moderate

Intravitreal fluocinolone acetonide implant 0.19 mg vs sham

Use of IOP‐lowering medications ‐ 24 months · macular edema in diabetes

Intravitreal fluocinolone acetonide implant 0.19 mg probably leads to higher use of IOP‐lowering medications ‐ 24 months compared with sham (moderate certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 2.72 [1.87, 3.98]
1 study · 558 participants
Moderate

Intravitreal fluocinolone acetonide implant 0.19 mg vs sham

Surgery for glaucoma ‐ 24 months · macular edema in diabetes

Intravitreal fluocinolone acetonide implant 0.19 mg may leads to higher surgery for glaucoma ‐ 24 months compared with sham (low certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 9.54 [1.28, 70.93]
1 study · 558 participants
Low

Intravitreal triamcinolone acetonide injection 4 mg vs sham

Visual acuity · macular edema in diabetes

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intravitreal dexamethasone implant 0.7 mg vs sham

Gain 3+ lines of visual acuity at 1 year · macular edema in diabetes

Intravitreal dexamethasone implant 0.7 mg showed no clear difference in gain of three or more lines visual acuity ‐ 12 months compared with sham (moderate certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 1.39 [0.91, 2.12]
1 study · 701 participants
Moderate

Intravitreal triamcinolone acetonide injection 4 mg vs sham

Gain of 3 or more lines of visual acuity · macular edema in diabetes

It is very uncertain whether intravitreal triamcinolone acetonide injection 4 mg changes gain of three or more lines visual acuity ‐ 24 months** compared with sham (very low certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 4.12 [0.48, 34.99]
Studies not reported
Very low

Intravitreal triamcinolone acetonide injection 4 mg vs sham

Change in retinal thickness (micron) (negative is better) · macular edema in diabetes

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intravitreal triamcinolone acetonide injection 4 mg vs sham

Cataract progression ‐ 24 months · macular edema in diabetes

Intravitreal triamcinolone acetonide injection 4 mg showed no clear difference in cataract progression ‐ 24 months compared with sham (low certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 3 [0.97, 9.3]
Studies not reported
Low

Intravitreal triamcinolone acetonide injection 4 mg vs sham

Use of IOP‐lowering medications ‐ 24 months · macular edema in diabetes

It is very uncertain whether intravitreal triamcinolone acetonide injection 4 mg changes use of IOP‐lowering medications ‐ 24 months compared with sham (very low certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 21.6 [1.32, 354.7]
Studies not reported
Very low

Intravitreal triamcinolone acetonide injection 4 mg vs sham

Surgery for glaucoma ‐ 24 months · macular edema in diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravitreal triamcinolone acetonide injection 4 mg vs macular laser

Change in visual acuity (logMAR) ‐ 12 months (negative is better) · macular edema in diabetes

It is very uncertain whether intravitreal triamcinolone acetonide injection 4 mg changes change in visual acuity (logMAR) ‐ 12 months (negative is better) compared with macular laser (very low certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
MD 0.02
Studies not reported
Very low

Intravitreal triamcinolone acetonide injection 4 mg vs macular laser

Gain 3+ lines of visual acuity at 1 year · macular edema in diabetes

Intravitreal triamcinolone acetonide injection 4 mg showed no clear difference in gain of three or more lines visual acuity ‐ 12 months compared with macular laser (low certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 0.85 [0.55, 1.3]
Studies not reported
Low

Intravitreal triamcinolone acetonide injection 4 mg vs macular laser

Change in retinal thickness (micron) (negative is better) · macular edema in diabetes

It is very uncertain whether intravitreal triamcinolone acetonide injection 4 mg changes change in retinal thickness (micron) (negative is better) compared with macular laser (very low certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
MD 5
Studies not reported
Very low

Intravitreal triamcinolone acetonide injection 4 mg vs macular laser

Cataract progression · macular edema in diabetes

Intravitreal triamcinolone acetonide injection 4 mg probably leads to higher cataract progression ‐ 9 to 24 months compared with macular laser (moderate certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 2.68 [2.21, 3.24]
Studies not reported
Moderate

Intravitreal triamcinolone acetonide injection 4 mg vs macular laser

Use of IOP‐lowering medications · macular edema in diabetes

Intravitreal triamcinolone acetonide injection 4 mg probably leads to higher use of IOP‐lowering medications ‐ 9 to 24 months compared with macular laser (moderate certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 3.92 [2.59, 5.96]
Studies not reported
Moderate

Intravitreal dexamethasone implant 0.7 mg vs sham

Change in retinal thickness (micron) (negative is better) · macular edema in diabetes

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 701 participants
Moderate

Intravitreal triamcinolone acetonide injection 4 mg vs macular laser

Surgery for glaucoma ‐ 24 months · macular edema in diabetes

Intravitreal triamcinolone acetonide injection 4 mg showed no clear difference in surgery for glaucoma ‐ 9 to 24 months compared with macular laser (low certainty).

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
RR 11.68 [0.63, 216]
Studies not reported
Low

Intravitreal triamcinolone acetonide injection 4 mg vs antiVEGF

Change in visual acuity (logMAR) ‐ 12 months (negative is better) · macular edema in diabetes

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Intravitreal triamcinolone acetonide injection 4 mg vs antiVEGF

Gain of 3 or more lines of visual acuity · macular edema in diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Intravitreal steroids for macular edema in diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found