Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,970 questions · 2,433 findings · 231 reviews

No studies found 303 · 12.5%GRADE not reported 759 · 31.2%Very low 357 · 14.7%Low 476 · 19.6%Moderate 418 · 17.2%High 120 · 4.9%

Salvadora persica (miswak) mouthrinse vs Placebo rinse

Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced Streptococcus mutans counts more than placebo (favours Salvadora persica); not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Placebo rinse

Plaque · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced plaque more than placebo (favours Salvadora persica); certainty not GRADE-rated (Shekelle grade Ia).

1 finding from 1 review

Chlorhexidine 0.12% mouthrinse vs Pre-treatment (baseline, same group)

Plaque · Medically healthy individuals (adults and children, 6-60 years)

0.12% chlorhexidine rinse reduced plaque relative to baseline; not GRADE-rated.

1 finding from 1 review

Salvadora persica (miswak) mouthrinse vs Pre-treatment (baseline, same group)

Plaque · Medically healthy individuals (adults and children, 6-60 years)

Salvadora persica rinse reduced plaque relative to its own baseline; not GRADE-rated.

1 finding from 1 review

Placebo rinse vs Pre-treatment (baseline, same group)

Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)

Placebo rinse did not significantly change Streptococcus mutans counts relative to baseline; not GRADE-rated.

1 finding from 1 review

Intervention not reported

In‐hospital death from any cause occurring within 4 weeks of randomization or the beginning of treatment · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Duration of hospitalization (in weeks) · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Duration of mechanical ventilation (in weeks) · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Duration of tube or parenteral feeding (in weeks) · individuals with infant botulism
1 finding from 1 review

Intervention not reported

Risk of adverse events (until time of hospital discharge) · individuals with infant botulism

The intervention showed no clear difference in risk of adverse events (until time of hospital discharge) (moderate certainty).

1 finding from 1 review

Intervention not reported

Fractures · individuals with osteoporotic vertebral fracture

It is very uncertain whether the intervention changes fractures (very low certainty).

1 finding from 1 review

Intervention not reported

Falls · individuals with osteoporotic vertebral fracture

It is very uncertain whether the intervention changes falls (very low certainty).

1 finding from 1 review

Intervention not reported

Pain Scale: VAS (0 to 10), pain subscale of Functional Status Index (0 to 10) Higher score indicates greater pain levels · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Intervention not reported

Physical performance: self‐report questionnaires Physical function subscale from the QUALEFFO‐41 Scale from 0 to 100 Lower scores indicate better physical function · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Intervention not reported

Disease‐specific quality of life QUALEFFO‐41 total score Scale from 0 to 100 Lower scores indicate better quality of life · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Interpersonal Psychotherapy for Depression (IPT‐D) vs Other Psychological Interventions

Substance use ‐ relapse · co‐occurring depression and substance use disorders

It is very uncertain whether interpersonal Psychotherapy for Depression (IPT‐D) changes substance use ‐ relapse compared with other Psychological Interventions (very low certainty).

1 finding from 1 review

Interpersonal Psychotherapy for Depression (IPT‐D) vs Other Psychological Interventions

Retention in treatment · co‐occurring depression and substance use disorders

It is very uncertain whether interpersonal Psychotherapy for Depression (IPT‐D) changes treatment retention compared with other Psychological Interventions (very low certainty).

1 finding from 1 review

Interpersonal Psychotherapy for Depression (IPT‐D) vs Other Psychological Interventions

Depression score · co‐occurring depression and substance use disorders
2 findings from 1 review