Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Adenoidectomy (with or without myringotomy) vs watchful waiting

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy (with or without myringotomy) changes presence or persistence of OME ‐ over 12 months № of participants:… compared with no treatment/watchful waiting (very low certainty).

1 finding from 1 review

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and bilateral ventilation tubes changes hearing: return to normal hearing at 6 to 9 months № of… compared with bilateral ventilation tubes only (very low certainty).

1 finding from 1 review

Adenoidectomy and bilateral ventilation tubes vs bilateral ventilation tubes only

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and bilateral ventilation tubes changes presence/persistence of OME ‐ over 12 months № of participants: 254… compared with bilateral ventilation tubes only (very low certainty).

1 finding from 1 review

Adenoidectomy and unilateral ventilation tube vs unilateral ventilation tube only

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether adenoidectomy and unilateral ventilation tube changes hearing: proportion of children with hearing returned to normal (12… compared with unilateral ventilation tube only (very low certainty).

1 finding from 1 review

Autoinflation vs no treatment

Proportion of children whose hearing is normal · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether autoinflation changes proportion of children whose hearing is normal compared with no treatment (very low certainty).

1 finding from 1 review

Autoinflation vs no treatment

Pain and distress related to the procedure: otalgia · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether autoinflation changes pain and distress related to the procedure: otalgia compared with no treatment (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether antibiotics changes hearing ‐ return to normal hearing (as complete improvement in… compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether antibiotics changes presence/persistence of OME compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Adverse event: anaphylaxis · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether antibiotics changes adverse event: anaphylaxis compared with placebo (very low certainty).

1 finding from 1 review

Antibiotics vs no treatment

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

Antibiotics may leads to lower presence/persistence of OME (up to 3 months) № of participants: 542… compared with no treatment (low certainty).

1 finding from 1 review

Oral steroids vs placebo

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

Oral steroids showed no clear difference in hearing ‐ return to normal hearing compared with placebo (moderate certainty).

1 finding from 1 review