Measures of renal function: change in TmP/GFR · children with X‐linked hypophosphataemia
It is very uncertain whether summary of findings ‐ recombinant growth hormone changes measures of renal function: change in TmP/GFR compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Body proportions: sitting height SDS · children with X‐linked hypophosphataemia
Summary of findings ‐ recombinant growth hormone showed no clear difference in body proportions: sitting height SDS compared with placebo or no intervention (moderate certainty).
1 finding from 1 review
Adverse effects · children with X‐linked hypophosphataemia
1 finding from 1 review
FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis
It is very uncertain whether inhalation of dornase alfa before changes FEV1 (% predicted) change from baseline compared with after airway clearance techniques (very low certainty).
1 finding from 1 review
MD 0.83
102 participants
Very low
Adverse effects · adults and children with cystic fibrosis
1 finding from 1 review
no estimate extracted
25 participants
Low
FVC (% predicted) Change from baseline · adults and children with cystic fibrosis
Inhalation of dornase alfa before showed no clear difference in FVC (% predicted) change from baseline compared with after airway clearance techniques (low certainty).
1 finding from 1 review
MD 1.06
77 participants
Low
Measures of QoL and symptom scores · adults and children with cystic fibrosis
1 finding from 1 review
no estimate extracted
102 participants
Very low
FEF25-75 · adults and children with cystic fibrosis
Inhalation of dornase alfa before showed no clear difference in FEF25-75 (% predicted) compared with after airway clearance techniques (low certainty).
1 finding from 1 review
no estimate extracted
25 participants
Low
Adverse effects · adults and children with cystic fibrosis
1 finding from 1 review
no estimate extracted
102 participants
Very low
FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis
Morning showed no clear difference in FEV1 (% predicted) change from baseline compared with evening inhalation of dornase alfa (low certainty).
1 finding from 1 review
no estimate extracted
25 participants
Low
FVC (% predicted) Change from baseline · adults and children with cystic fibrosis
Morning showed no clear difference in FVC (% predicted) change from baseline compared with evening inhalation of dornase alfa (low certainty).
1 finding from 1 review
no estimate extracted
25 participants
Low
Measures of QoL and symptom scores · adults and children with cystic fibrosis
1 finding from 1 review
no estimate extracted
25 participants
Low
FEF25-75 · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Ulcer healing · individuals with sickle cell disease and a leg ulcer
It is very uncertain whether isoxsuprine changes complete leg ulcer closure (defined as 100% epithelization or skin… compared with placebo (very low certainty).
1 finding from 1 review
Change in ulcer size · individuals with sickle cell disease and a leg ulcer
1 finding from 1 review
Ulcer‐free survival following treatment for SCLU (free from leg ulcer recurrence) ‐ not reported · individuals with sickle cell disease and a leg ulcer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life ‐ not reported · individuals with sickle cell disease and a leg ulcer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Amputation ‐ not reported · individuals with sickle cell disease and a leg ulcer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · individuals with sickle cell disease and a leg ulcer
1 finding from 1 review
Complete leg ulcer closure ‐ not reported · individuals with sickle cell disease and a leg ulcer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found