Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Prophylactic corticosteroids vs placebo or no corticosteroids

Gastrointestinal bleeding · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids showed no clear difference in gastrointestinal (GI) bleeding (as defined by study authors,… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Prophylactic corticosteroids vs placebo or no corticosteroids

Renal failure · adults diagnosed with coronary artery disease or cardiac valve disease, and candidates for cardiac surgery with cardiopulmonary bypass

Prophylactic corticosteroids showed no clear difference in renal failure (as defined by study authors, including dialysis,… compared with placebo or no corticosteroids (low certainty).

1 finding from 1 review

Immune‐enhancing supplements (oral or enteral) vs usual care or control

Infectious complications · people undergoing gastrointestinal surgery

Immune‐enhancing supplements (oral or enteral) showed no clear difference in infectious complications recorded up to 30 days postdischarge compared with usual care or control (low certainty).

1 finding from 1 review

Oral nutritional supplements vs usual care or control

Infectious complications · people undergoing gastrointestinal surgery

It is very uncertain whether oral nutritional supplements changes infectious complications recorded up to 30 days postdischarge compared with usual care or control (very low certainty).

1 finding from 1 review

Preoperative enteral nutrition (standard formula) vs usual care or control

Infectious complications · people undergoing gastrointestinal surgery

It is very uncertain whether preoperative enteral nutrition (standard formula) changes infectious complications compared with usual care or control (very low certainty).

1 finding from 1 review

Immune‐enhancing supplements (oral or enteral) vs usual care or control

Non‐infectious complications · people undergoing gastrointestinal surgery

Immune‐enhancing supplements (oral or enteral) showed no clear difference in non‐ infectious complications recorded up to 30 days postdischarge compared with usual care or control (low certainty).

1 finding from 1 review

Probiotics vs placebo

Proven sepsis (positive bacterial culture, local or systemic) · neonates born from 35 weeks of gestation who have underdone gastrointestinal surgery

Summary of findings table ‐ Probiotics showed no clear difference in proven sepsis (positive bacterial culture, local or systemic) compared with placebo (low certainty).

1 finding from 1 review