Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Face‐down positioning vs no face‐down positioning or posturing after macular hole surgery

Closure of macular hole · participants with idiopathic macular hole

Face‐down positioning or posturing showed no clear difference in macular hole closure (anatomical assessment) compared with no face‐down positioning or posturing after macular hole surgery (low certainty).

1 finding from 1 review

Face‐down positioning vs no face‐down positioning or posturing after macular hole surgery

Improved visual acuity (ETDRS chart at 4 metres) · participants with idiopathic macular hole

It is very uncertain whether face‐down positioning or posturing changes improved visual acuity (ETDRS chart at 4 metres) compared with no face‐down positioning or posturing after macular hole surgery (very low certainty).

1 finding from 1 review

Prehabilitation vs no prehabilitation

Complications within 30 days postoperatively · Patients with outcomes after colorectal cancer surgery

Prehabilitation showed no clear difference in complications within 30 days postoperatively compared with no prehabilitation (low certainty).

1 finding from 1 review

Percutaneous nephrolithotomy vs retrograde intrarenal surgery

Ureteral stricture or injury Assumed MCID: 2% · adults with renal stones

Percutaneous nephrolithotomy showed no clear difference in ureteral stricture or injury Assumed MCID: 2% compared with retrograde intrarenal surgery (low certainty).

1 finding from 1 review

Summary of findings: Fibrin sealant vs usual care

Risk of a thrombotic/thromboembolic event (MI, CVA, DVT, PE) · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Fibrin sealant changes risk of a thrombotic/thromboembolic event (MI, CVA, DVT, PE) compared with usual care (very low certainty).

1 finding from 1 review

Tranexamic acid vs placebo

Risk of receiving any allogeneic blood product (data only available for intraoperative blood product use) · people aged 18 and over undergoing vascular surgery

It is very uncertain whether summary of findings: Tranexamic acid changes risk of receiving any allogeneic blood product (data only available… compared with placebo (very low certainty).

1 finding from 1 review