Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,718 questions · 1,762 findings · 100 reviews · Headline outcomes only

No studies found 507 · 28.8%GRADE not reported 115 · 6.5%Very low 556 · 31.6%Low 444 · 25.2%Moderate 114 · 6.5%High 26 · 1.5%

NSAIDs vs placebo

Patient Global Impression of Change much or very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

It is very uncertain whether non‐steroidal anti‐inflammatory drugs (NSAID) changes PGIC much or very much improved ( compared with placebo (very low certainty).

1 finding from 1 review

Alpha‐blockers vs placebo

Prostatitis symptoms · participants with chronic prostatitis/chronic pelvic pain syndrome
2 findings from 1 review

Antibiotics vs placebo

Prostatitis symptoms: 'responders' Number of participants with a 25% or 6‐point decrease in NIH‐CPSI scores · participants with chronic prostatitis/chronic pelvic pain syndrome

Antibiotic therapy showed no clear difference in prostatitis symptoms: 'responders' Number of participants with a 25%… compared with placebo (low certainty).

1 finding from 1 review